ArticleMolecular and cellular biology2001
Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Enhancer Dynamics and Spatial Organization Drive Anatomically Restricted Cellular States in the Human Spinal Cord.bioRxiv : the preprint server for biology · 2025Article
- Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.Scientific reports · 2020Article
- Article
- Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.Development (Cambridge, England) · 2009Article
- Characterization of Nkx6-2-derived neocortical interneuron lineages.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
- Specificity of four monoclonal anti-NKx6-1 antibodies.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The Nkx homeobox genes are expressed in a variety of developing tissues and have been implicated in controlling tissue patterning and cell differentiation. Expression of Nkx6.2 (Gtx) was previously observed in the embryonic neural tube, testis, and differentiating oligodendrocytes. To investigate the role of Nkx6.2 in the control of cell specification and differentiation, we generated mice with null mutations in Nkx6.2 using the standard gene targeting approach. Null mutant mice were viable and fertile without apparent histological and immunohistochemical changes in the central nervous systems and testis. The absence of detectable phenotypes suggests a redundant function of Nkx6.2 in mouse development.
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Registered trials
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