ArticleJournal of virology2001
Identification of a novel transcriptional repressor encoded by human cytomegalovirus.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- UL34 Deletion Restricts Human Cytomegalovirus Capsid Formation and Maturation.International journal of molecular sciences · 2022Article
- Mouse CytomegalovirusFrontiers in cellular and infection microbiology · 2020Article
- pUL34 binding near the human cytomegalovirus origin of lytic replication enhances DNA replication and viral growth.Virology · 2018Article
- Article
- Human cytomegalovirus UL34 early and late proteins are essential for viral replication.Viruses · 2014Article
- Nontraditional localization and retention signals localize human cytomegalovirus pUL34 to the nucleus.Journal of virology · 2013Article
- Human cytomegalovirus UL34 binds to multiple sites within the viral genome.Journal of virology · 2013Article
- Characterization of the human cytomegalovirus UL34 gene.Journal of virology · 2004Article
- Reevaluation of human cytomegalovirus coding potential.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The human cytomegalovirus UL35 gene encodes two proteins with different functions.Journal of virology · 2002Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of human cytomegalovirus (HCMV) genes during viral replication is precisely regulated, with the interactions of both transcriptional activators and repressors determining the level of gene expression. One gene of HCMV, the US3 gene, is transcriptionally repressed early in infection. Repression of US3 expression requires viral infection and protein synthesis and is mediated through a DNA sequence, the transcriptional repressive element. In this report, we identify the protein that represses US3 transcription as the product of the HCMV UL34 open reading frame. The protein encoded by UL34 (pUL34) binds to the US3 transcriptional repressive element in yeast and in vitro. pUL34 localizes to the nucleus and alone is sufficient for repression of US3 expression. The data presented here, along with earlier data (B. J. Biegalke, J. Virol. 72:5457-5463, 1998), suggests that pUL34 binding of the transcriptional repressive element prevents transcription initiation complex formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.