ArticleThe Journal of experimental medicine2001
Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 60 citations in OpenAlex.
- Comparative Analysis of Immune Activation Markers of CD8Frontiers in immunology · 2016Article
- Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IκBα.The Journal of experimental medicine · 2015Article
- Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity.PLoS biology · 2009Article
- The absence of cutaneous lymph nodes results in a Th2 response and increased susceptibility to Leishmania major infection in mice.Infection and immunity · 2008Article
- Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue.The Journal of experimental medicine · 2007Article
- Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin.Immunology · 2005Article
- Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control.The Journal of experimental medicine · 2003Article
- A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT.The Journal of clinical investigation · 2003Article
- Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells.The Journal of experimental medicine · 2003Article
- Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.The Journal of experimental medicine · 2003Article
- Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches.The American journal of pathology · 2002Article
- Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway.The Journal of clinical investigation · 2002Article
- Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis.The Journal of experimental medicine · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymph nodes (LNs) are important sentinal organs, populated by circulating lymphocytes and antigen-bearing cells exiting the tissue beds. Although cellular and humoral immune responses are induced in LNs by antigenic challenge, it is not known if LNs are essential for acquired immunity. We examined immune responses in mice that lack LNs due to genetic deletion of lymphotoxin ligands or in utero blockade of membrane lymphotoxin. We report that LNs are absolutely required for generating contact hypersensitivity, a T cell-dependent cellular immune response induced by epicutaneous hapten. We show that the homing of epidermal Langerhans cells in response to hapten application is specifically directed to LNs, providing a cellular basis for this unique LN function. In contrast, the spleen cannot mediate contact hypersensitivity because antigen-bearing epidermal Langerhans cells do not access splenic white pulp. Finally, we formally demonstrate that LNs provide a unique environment essential for generating this acquired immune response by reversing the LN defect in lymphotoxin-alpha(-/)- mice, thereby restoring the capacity for contact hypersensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.