ArticleThe Journal of clinical investigation2001
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 160 citations in OpenAlex.
- A novel trypsin of Trichinella spiralis mediates larval invasion of gut epithelium via binding to PAR2 and activating ERK1/2 pathway.PLoS neglected tropical diseases · 2024Article
- Topographical distribution and morphology of SP-IR axons in the antrum, pylorus, and duodenum of mice.Autonomic neuroscience : basic & clinical · 2023Article
- Proteolytic activity ofThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Neuro-innate immune interactions in gut mucosal immunity.Current opinion in immunology · 2021Review
- The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals.Frontiers in immunology · 2020Review
- Bioengineered in vitro enteric nervous system.Journal of tissue engineering and regenerative medicine · 2019Article
- Preventive Effect ofFoods (Basel, Switzerland) · 2019Article
- Small Intestine Protection of Mica Against Non-Steroidal Anti-Inflammatory Drugs-Injury Through ERK1/2 Signal Pathway in Rats.Frontiers in pharmacology · 2019Article
- Preventive Effect of Raw Liubao Tea Polyphenols on Mouse Gastric Injuries Induced by HCl/Ethanol via Anti-Oxidative Stress.Molecules (Basel, Switzerland) · 2018Article
- Proteinase activated-receptors-associated signaling in the control of gastric cancer.World journal of gastroenterology · 2014Review
- Proteinase-activated receptor 2 activation promotes an anti-inflammatory and alternatively activated phenotype in LPS-stimulated murine macrophages.Innate immunity · 2012Article
- Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38.The American journal of pathology · 2011Article
- Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides.The Journal of physiology · 2010Article
- Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo.Mucosal immunology · 2010Article
- Over-expression and localization of a host protein on the membrane of Cryptosporidium parvum infected epithelial cells.Molecular and biochemical parasitology · 2009Article
- Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo.British journal of pharmacology · 2009Article
- Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.British journal of pharmacology · 2008Review
- Gastrointestinal roles for proteinase-activated receptors in health and disease.British journal of pharmacology · 2008Review
- Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro.The international journal of biochemistry & cell biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, modulates smooth muscle tone and exocrine secretion in the salivary glands and pancreas. Given that PAR-2 is expressed throughout the gastrointestinal tract, we investigated effects of PAR-2 agonists on mucus secretion and gastric mucosal injury in the rat. PAR-2-activating peptides triggered secretion of mucus in the stomach, but not in the duodenum. This mucus secretion was abolished by pretreatment with capsaicin, which stimulates and ablates specific sensory neurons, but it was resistant to cyclo-oxygenase inhibition. In contrast, capsaicin treatment failed to block PAR-2-mediated secretion from the salivary glands. Intravenous calcitonin gene-related peptide (CGRP) and neurokinin A markedly elicited gastric mucus secretion, as did substance P to a lesser extent. Specific antagonists of the CGRP1 and NK2, but not the NK1, receptors inhibited PAR-2-mediated mucus secretion. Pretreatment with the PAR-2 agonist strongly prevented gastric injury caused by HCl-ethanol or indomethacin. Thus, PAR-2 activation triggers the cytoprotective secretion of gastric mucus by stimulating the release of CGRP and tachykinins from sensory neurons. In contrast, the PAR-2-mediated salivary exocrine secretion appears to be independent of capsaicin-sensitive sensory neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.