ArticleGenes & development2001
A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers.
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Who cites it
176 citing papers in PubMed, 331 citations in OpenAlex.
- Interaction Between Rec8 and Mis4 Is Required for Axis-Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Early resolution of sister chromatids during C. elegans meiosis.The Journal of cell biology · 2026Article
- Active maintenance of meiosis-specific chromosome structures inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Direct binding of chromosome axis and cohesin complexes underlies meiotic chromosome architecture in fungi and plants.bioRxiv : the preprint server for biology · 2026Article
- Cohesin forms fountains at active enhancers in C. elegans.Nature communications · 2025Article
- Mutual, spatially limited control of meiotic DNA break formation by Mre11-Rad50-Nbs1 DNA repair complex and Tel1 (ATM) protein kinase.Nucleic acids research · 2025Article
- Loss of meiotic double strand breaks triggers recruitment of recombination-independent pro-crossover factors in C. elegans spermatogenesis.PLoS genetics · 2025Article
- Active maintenance of meiosis-specific chromosome structures inbioRxiv : the preprint server for biology · 2025Article
- Cohesin ring gates are specialized for meiotic cell division.Journal of molecular cell biology · 2025Article
- Identification of the Polo-like kinase substrate required for homologous synapsis.The Journal of cell biology · 2025Article
- Induction of somatic cell haploidy by premature cell division.Science advances · 2024Article
- Article
- Building the synaptonemal complex: Molecular interactions between the axis and the central region.PLoS genetics · 2023Review
- A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes.The EMBO journal · 2023Article
- Genome-Wide Analysis of theGenes · 2023Article
- ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells.Nature structural & molecular biology · 2023Article
- Meiotic DNA exchanges inLife science alliance · 2023Article
- Meiotic cells escape prolonged spindle checkpoint activity through kinetochore silencing and slippage.PLoS genetics · 2023Article
- Meiotic Cells Escape Prolonged Spindle Checkpoint Activity Through Premature Silencing and Slippage.bioRxiv : the preprint server for biology · 2023Article
- Oogenesis in Caenorhabditis elegans.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2023Review
116 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied four Caenorhabditis elegans homologs of the Rad21/Scc1/Rec8 sister-chromatid cohesion protein family. Based on the RNAi phenotype and protein localization, it is concluded that one of them, W02A2.6p, is the likely worm ortholog of yeast Rec8p. The depletion of C. elegans W02A2.6p (called REC-8) by RNAi, induced univalent formation and splitting of chromosomes into sister chromatids at diakinesis. Chromosome synapsis at pachytene was defective, but primary homology recognition seemed unaffected, as a closer-than-random association of homologous fluorescence in situ hybridization (FISH) signals at leptotene/zygotene was observed. Depletion of REC-8 also induced chromosome fragmentation at diakinesis. We interpret these fragments as products of unrepaired meiotic double-stranded DNA breaks (DSBs), because fragmentation was suppressed in a spo-11 background. Thus, REC-8 seems to be required for successful repair of DSBs. The occurrence of DSBs in REC-8-depleted meiocytes suggests that DSB formation does not depend on homologous synapsis. Anti-REC-8 immunostaining decorated synaptonemal complexes (SCs) at pachytene and chromosomal axes in bivalents and univalents at diakinesis. Between metaphase I and metaphase II, REC-8 is partially lost from the chromosomes. The partial loss of REC-8 from chromosomes between metaphase I and metaphase II suggests that worm REC-8 might function similarly to yeast Rec8p. The loss of yeast Rec8p from chromosome arms at meiosis I and centromeres at meiosis II coordinates the disjunction of homologs and sister chromatids at the two meiotic divisions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.