ArticleThe Biochemical journal2001
Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Monoamine oxidase mediated oxidative stress: a potential molecular and biochemical crux in the pathogenesis of obesity.Molecular biology reports · 2023Review
- Effects of Chemical Structures Interacting with Amine Oxidases on Glucose, Lipid and Hydrogen Peroxide Handling by Human Adipocytes.Molecules (Basel, Switzerland) · 2022Article
- Hyperglycemia and reduced adiposity of streptozotocin-induced diabetic mice are not alleviated by oral benzylamine supplementation.World journal of diabetes · 2022Article
- Oral Supplementation with Benzylamine Delays the Onset of Diabetes in Obese and Diabetic db-/- Mice.Nutrients · 2021Article
- Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.Journal of physiology and biochemistry · 2021Article
- Inhibition of vascular adhesion protein-1 modifies hepatic steatosisWorld journal of hepatology · 2020Article
- Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors.Medicines (Basel, Switzerland) · 2019Review
- 5-hydroxytryptamine actions in adipocytes: involvement of monoamine oxidase-dependent oxidation and subsequent PPARγ activation.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells.Amino acids · 2012Article
- Hepatic consequences of vascular adhesion protein-1 expression.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray study.American journal of physiology. Endocrinology and metabolism · 2011Article
- Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue.Journal of obesity · 2011Article
- The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites.The EMBO journal · 2010Article
- Semicarbazide-sensitive amine oxidase substrates fail to induce insulin-like effects in fat cells from AOC3 knockout mice.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
- Amine oxidase substrates for impaired glucose tolerance correction.Journal of physiology and biochemistry · 2005Review
- Influence of high-fat diet on amine oxidase activity in white adipose tissue of mice prone or resistant to diet-induced obesity.Journal of physiology and biochemistry · 2005Article
- Effect of prolonged treatment with tyramine on glucose tolerance in streptozotocin-induced diabetic rats.Journal of physiology and biochemistry · 2003Article
- Tyramine and benzylamine partially but selectively mimic insulin action on adipose differentiation in 3T3-L1 cells.Journal of physiology and biochemistry · 2003Article
- Effect of tyramine, a dietary amine, on glycerol and lactate release by isolated adipocytes from old rats.Journal of physiology and biochemistry · 2003Article
- Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats.Journal of physiology and biochemistry · 2003Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously reported that substrates of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) exert short-term insulin-like effects in rat adipocytes, such as stimulation of glucose transport. In the present work, we studied whether these substrates could also mimic long-term actions of insulin. Adipose differentiation of 3T3 F442A cells, which is highly insulin-dependent, served as a model to test the effects of sustained administration of amine oxidase substrates. Daily treatment of confluent cells with 0.75 mM tyramine (a substrate of MAO and SSAO) or benzylamine (a substrate of SSAO) over 1 week caused the acquisition of typical adipocyte morphology. The stimulation of protein synthesis and triacylglycerol accumulation caused by tyramine or benzylamine reached one half of that promoted by insulin. This effect was insensitive to pargyline (an MAO inhibitor), but was inhibited by semicarbazide (an SSAO inhibitor) and by N-acetylcysteine (an antioxidant agent), suggesting the involvement of the H(2)O(2) generated during SSAO-dependent amine oxidation. Chronic administration of amine oxidase substrates also induced the emergence of adipose conversion markers, such as aP2, glycerol-3-phosphate dehydrogenase, the glucose transporter GLUT4, and SSAO itself. Moreover, cells treated with amines acquired the same insulin sensitivity regarding glucose transport as adipocytes classically differentiated with insulin. In all, most of the adipogenic effects of amines were additive to insulin. Our data reveal that amine oxidase substrates partially mimic the adipogenic effect of insulin in cultured preadipocytes. Furthermore, they suggest that SSAO not only represents a novel late marker of adipogenesis, but could also be directly involved in the triggering of terminal adipocyte differentiation.
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