ArticleThe Biochemical journal2001
Endosomal localization of phospholipase D 1a and 1b is defined by the C-termini of the proteins, and is independent of activity.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Mammalian phospholipase D: Function, and therapeutics.Progress in lipid research · 2020Review
- Expression of endogenous phospholipase D1, localized in mouse submandibular gland, is greater in females and is suppressed by testosterone.Journal of anatomy · 2019Article
- Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking.Nature communications · 2019Article
- Clickable Substrate Mimics Enable Imaging of Phospholipase D Activity.ACS central science · 2017Article
- Chemical modulation of glycerolipid signaling and metabolic pathways.Biochimica et biophysica acta · 2014Review
- Role of phospholipase d in g-protein coupled receptor function.Membranes · 2014Article
- Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations.International journal of molecular sciences · 2013Article
- Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation.The Journal of biological chemistry · 2011Article
- Phospholipase D: enzymology, functionality, and chemical modulation.Chemical reviews · 2011Review
- Phospholipase D signaling: orchestration by PIP2 and small GTPases.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors.Molecular biology of the cell · 2006Article
- Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs.The Journal of cell biology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The factors regulating the activity of cellular phospholipase D (PLD) have been well characterized; however, the cellular distribution of specific PLD isoforms and the factors defining localization are less clear. Two specific PLD1 isoforms, PLD1a and PLD1b, are shown in the present study to be localized in endosomal compartments with early endosomal autoantigen 1, internalizing epidermal growth factor receptor (ErbB1) and lysobisphosphatidic acid. Novel C-terminal splice variants of PLD1, PLD1a2 and PLD1b2, do not exhibit this endosomal localization. Studies using catalytically inactive and C-terminal deletion mutants of the four PLD1 isoforms led to the conclusion that the C-terminus plays an important part in the catalytic activity of PLD1, but that the endosomal localization of PLD1a and PLD1b is defined by the C-terminus and not catalytic activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.