Trial reportThe Journal of physiology2001
Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans.
Trial report in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- The Effect of Gut-Training and Feeding-Challenge on Markers of Gastrointestinal Status in Response to Endurance Exercise: A Systematic Literature Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Journal of diabetes research · 2016Pooled it
- Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis.European journal of clinical nutrition · 2007Pooled it
- Training with reduced carbohydrate availability affects markers of bone resorption and formation in male academy soccer players from the English Premier League.European journal of applied physiology · 2024Trial
- Effect of time of day and partial sleep deprivation on plasma concentrations of IL-6 during a short-term maximal performance.European journal of applied physiology · 2013Trial
- Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle.The Journal of physiology · 2004Trial
- IL-6 gene expression in human adipose tissue in response to exercise--effect of carbohydrate ingestion.The Journal of physiology · 2003Trial
- Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans.The Journal of physiology · 2003Trial
- Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans.The Journal of physiology · 2003Trial
- Cytokine response to resistance exercise in children with excess adiposity and Prader-Willi syndrome.Physiological reports · 2025Article
- A bi-variate framework to model microbiome resilience in healthy dogs.Frontiers in veterinary science · 2025Article
- Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2024Article
- Advancing cancer cachexia diagnosis with -omics technology and exercise as molecular medicine.Sports medicine and health science · 2024Review
- Article
- Implications of Adipose Tissue Content for Changes in Serum Levels of Exercise-Induced Adipokines: A Quasi-Experimental Study.International journal of environmental research and public health · 2022Article
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Effect of Various Exercise Regimens on Selected Exercise-Induced Cytokines in Healthy People.International journal of environmental research and public health · 2021Review
- The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations.Frontiers in physiology · 2021Review
- Characterization and Modulation of Systemic Inflammatory Response to Exhaustive Exercise in Relation to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2020Review
- Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle.Nutrients · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle and plasma IL-6 concentration. 2. Seven moderately trained men completed 60 min of exercise at a workload corresponding to each individual's lactate threshold on four randomised occasions. Two trials were conducted on a bicycle ergometer (Cyc) and two on a running treadmill (Run) either with (CHO) or without (Con) the ingestion of a CHO beverage throughout the exercise. Muscle biopsies were obtained from the vastus lateralis before and immediately after exercise and IL-6 gene expression in these samples was determined using real-time PCR. In addition, venous blood samples were collected at rest, and after 30 min during and at the cessation of exercise. These samples were analysed for plasma IL-6. 3. Irrespective of exercise mode or CHO ingestion, exercise resulted in a 21 +/- 4-fold increase (P < 0.01; main exercise effect) in IL-6 mRNA expression. In contrast, while the mode of exercise did not affect the exercise-induced increase in plasma IL-6, CHO ingestion blunted (P < 0.01) this response. 4. These data demonstrate that CHO ingestion attenuates the plasma IL-6 concentration during both cycling and running exercise. However, because IL-6 mRNA expression was unaffected by CHO ingestion, it is likely that the ingestion of CHO during exercise attenuates IL-6 production by tissues other than skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.