ArticleThe Journal of physiology2001
Novel voltage-dependent non-selective cation conductance in murine colonic myocytes.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.Scientific reports · 2020Article
- NaFrontiers in physiology · 2020Article
- Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present.Pflugers Archiv : European journal of physiology · 2015Review
- Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.British journal of pharmacology · 2011Article
- Phospholipase C-independent effects of 3M3FBS in murine colon.European journal of pharmacology · 2010Article
- Voltage-dependent Ca Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Role of Ca2+ entry and Ca2+ stores in atypical smooth muscle cell autorhythmicity in the mouse renal pelvis.British journal of pharmacology · 2007Article
- Pacemaker currents modulated by C-type natriuretic peptide in interstitial cells of cajal from murine small intestine.Journal of physiology and biochemistry · 2006Article
- Localised calcium release events in cells from the muscle of guinea-pig gastric fundus.The Journal of physiology · 2004Article
- Properties of pacemaker potentials recorded from myenteric interstitial cells of Cajal distributed in the mouse small intestine.The Journal of physiology · 2003Article
- T- and L-type Ca2+ currents in freshly dispersed smooth muscle cells from the human proximal urethra.The Journal of physiology · 2003Article
- Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes.British journal of pharmacology · 2003Article
- Voltage-dependent inward currents of interstitial cells of Cajal from murine colon and small intestine.The Journal of physiology · 2002Article
- A Ca(2+)-inhibited non-selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal.The Journal of physiology · 2002Article
- The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
1. Two components of voltage-gated, inward currents were observed from murine colonic myocytes. One component had properties of L-type Ca(2+) currents and was inhibited by nicardipine (5 x 10(-7) M). A second component did not 'run down' during dialysis and was resistant to nicardipine (up to 10(-6) M). The nicardipine-insensitive current was activated by small depolarizations above the holding potential and reversed near 0 mV. 2. This low-voltage-activated current (I(LVA)) was resolved with step depolarizations positive to -60 mV, and the current rapidly inactivated upon sustained depolarization. The voltage of half-inactivation was -65 mV. Inactivation and activation time constants at -45 mV were 86 and 15 ms, respectively. The half-recovery time from inactivation was 98 ms at -45 mV. I(LVA) peaked at -40 mV and the current reversed at 0 mV. 3. I(LVA) was inhibited by Ni(2+) (IC(50) = 1.4 x 10(-5) M), mibefradil (10(-6) to 10(-5) M), and extracellular Ba(2+). Replacement of extracellular Na(+) with N-methyl-D-glucamine inhibited I(LVA) and shifted the reversal potential to -7 mV. Increasing extracellular Ca(2+) (5 x 10(-3) M) increased the amplitude of I(LVA) and shifted the reversal potential to +22 mV. I(LVA) was also blocked by extracellular Cs(+) (10(-4) M) and Gd(3+) (10(-6) M). 4. Warming increased the rates of activation and deactivation without affecting the amplitude of the peak current. 5. We conclude that the second component of voltage-dependent inward current in murine colonic myocytes is not a 'T-type' Ca(2+) current but rather a novel, voltage-gated non-selective cation current. Activation of this current could be important in the recovery of membrane potential following inhibitory junction potentials in gastrointestinal smooth muscle or in mediating responses to agonists.
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