ArticleThe EMBO journal2001
Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Over-expression of Hsp83 in grossly depletedJournal of biosciences · 2019Article
- HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes.Cell division · 2019Article
- Plk1 is essential for proper chromosome segregation during meiosis I/meiosis II transition in pig oocytes.Reproductive biology and endocrinology : RB&E · 2017Article
- The Centrioles, Centrosomes, Basal Bodies, and Cilia ofGenetics · 2017Review
- Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells.Immunologic research · 2016Article
- Multifunctional Microtubule-Associated Proteins in Plants.Frontiers in plant science · 2016Review
- Understanding the Polo Kinase machine.Oncogene · 2015Review
- HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.PloS one · 2014Article
- Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins.Cell cycle (Georgetown, Tex.) · 2014Article
- Regulation of Greatwall kinase by protein stabilization and nuclear localization.Cell cycle (Georgetown, Tex.) · 2014Article
- The therapeutic target Hsp90 and cancer hallmarks.Current pharmaceutical design · 2013Review
- MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin.Journal of cell science · 2012Article
- Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans.Molecular biology of the cell · 2012Article
- Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.The Journal of biological chemistry · 2011Article
- Article
- Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.Developmental cell · 2009Article
- Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization.The EMBO journal · 2009Article
- Heat shock proteins in animal neoplasms and human tumours--a comparison.Cell stress & chaperones · 2008Review
- Arsenite-induced mitotic death involves stress response and is independent of tubulin polymerization.Toxicology and applied pharmacology · 2008Article
- The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex.Human genetics · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that the molecular chaperone heat shock protein 90 (Hsp90) is required to ensure proper centrosome function in Drosophila and vertebrate cells. This observation led to the hypothesis that this chaperone could be required for the stability of one or more centrosomal proteins. We have found that one of these is Polo, a protein kinase known to regulate several aspects of cell division including centrosome maturation and function. Inhibition of Hsp90 results in the inactivation of Polo kinase activity. It also leads to a loss in the ability of cytoplasmic extracts to complement the failure of salt-stripped preparations of centrosomes to nucleate microtubules. This effect can be rescued upon addition of active recombinant POLO: We also show that Polo and Hsp90 are part of a complex and conclude that stabilization of Polo is one of the mechanisms by which Hsp90 contributes to the maintenance of functional centrosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.