ArticleThe EMBO journal2001
Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 136 citations in OpenAlex.
- RNA Pol-II transcripts in nucleolar associated domains of cancer cell nucleoli.Nucleus (Austin, Tex.) · 2025Article
- LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells.Genes & development · 2025Article
- Nucleolus and centromere Tyramide Signal Amplification-Seq reveals variable localization of heterochromatin in different cell types.Communications biology · 2024Article
- Anomalous coarsening of coalescing nucleoli in human cells.Biophysical journal · 2024Article
- Transient crosslinking controls the condensate formation pathway within chromatin networks.Physical review. E · 2024Article
- New Functional Motifs for the Targeted Localization of Proteins to the Nucleolus inInternational journal of molecular sciences · 2024Article
- Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli.Cellular and molecular life sciences : CMLS · 2023Article
- Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains.Nature communications · 2022Article
- WDR43 is a potential diagnostic biomarker and therapeutic target for osteoarthritis complicated with Parkinson's disease.Frontiers in cellular neuroscience · 2022Article
- Review
- Human nucleoli comprise multiple constrained territories, tethered to individual chromosomes.Genes & development · 2021Article
- The Role ofInternational journal of molecular sciences · 2021Review
- The genomic structure of a human chromosome 22 nucleolar organizer region determined by TAR cloning.Scientific reports · 2021Article
- Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021Review
- The rich inner life of the cell nucleus: dynamic organization, active flows, and emergent rheology.Biophysical reviews · 2020Review
- NORs on human acrocentric chromosome p-arms are active by default and can associate with nucleoli independently of rDNA.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Human NORs, comprising rDNA arrays and functionally conserved distal elements, are located within dynamic chromosomal regions.Genes & development · 2019Article
- Article
- Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin.Genome research · 2019Article
- Potential effects of xylopic acid on acetic acid-induced ulcerative colitis in rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human ribosomal gene repeats are distributed among five nucleolar organizer regions (NORs) on the p arms of acrocentric chromosomes. On exit from mitosis, nucleoli form around individual active NORs. As cells progress through the cycle, these mini-nucleoli fuse to form large nucleoli incorporating multiple NORs. It is generally assumed that nucleolar incorporation of individual NORs is dependent on ribosomal gene transcription. To test this assumption, we determined the nuclear location of individual human acrocentric chromosomes, and their associated NORs, in mouse> human cell hybrids. Human ribosomal genes are transcriptionally silent in this context. Combined immunofluorescence and in situ hybridization (immuno-FISH) on three-dimensional preserved nuclei showed that human acrocentric chromosomes associate with hybrid cell nucleoli. Analysis of purified nucleoli demonstrated that human and mouse NORs are equally likely to be within a hybrid cell nucleolus. This is supported further by the observation that murine upstream binding factor can associate with human NORs. Incorporation of silent NORs into mature nucleoli raises interesting issues concerning the maintenance of the activity status of individual NORs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.