ArticleThe EMBO journal2001
Energized mitochondria increase the dynamic range over which inositol 1,4,5-trisphosphate activates store-operated calcium influx.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 121 citations in OpenAlex.
- Cross Talking Calcium, IPCell biochemistry and biophysics · 2024Article
- Targeting mitochondrial CaThe Journal of physiology · 2024Review
- Multifaceted control of T cell differentiation by STIM1.Trends in biochemical sciences · 2023Review
- Spatio temporal interdependent calcium and buffer dynamics regulating DAG in a hepatocyte cell due to obesity.Journal of bioenergetics and biomembranes · 2023Article
- The interplay between mitochondria and store-operated CaJournal of cellular and molecular medicine · 2021Review
- Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated ImmunityFrontiers in pharmacology · 2021Article
- Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated CaFrontiers in physiology · 2019Article
- Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome.Neural regeneration research · 2018Article
- The machineries, regulation and cellular functions of mitochondrial calcium.Nature reviews. Molecular cell biology · 2018Review
- Mitochondrial junctions with cellular organelles: CaPflugers Archiv : European journal of physiology · 2018Review
- T Cell Calcium Signaling Regulation by the Co-Receptor CD5.International journal of molecular sciences · 2018Review
- Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs.Oncotarget · 2017Article
- Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.Nature reviews. Cardiology · 2017Review
- Mitochondria control store-operated CaThe EMBO journal · 2017Article
- Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome.Scientific reports · 2016Article
- Store-Operated Calcium Channels.Physiological reviews · 2015Review
- Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.Science signaling · 2015Article
- Dysregulated Ca2+ homeostasis in Fanconi anemia cells.Scientific reports · 2015Article
- IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake.Journal of cell science · 2014Article
- Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic cells, activation of cell surface receptors that couple to the phosphoinositide pathway evokes a biphasic increase in intracellular free Ca2+ concentration: an initial transient phase reflecting Ca2+ release from intracellular stores, followed by a plateau phase due to Ca2+ influx. A major component of this Ca2+ influx is store-dependent and often can be measured directly as the Ca2+ release-activated Ca2+ current (I(CRAC)). Under physiological conditions of weak intracellular Ca2+ buffering, respiring mitochondria play a central role in store-operated Ca2+ influx. They determine whether macroscopic I(CRAC) activates or not, to what extent and for how long. Here we describe an additional role for energized mitochondria: they reduce the amount of inositol 1,4,5-trisphosphate (InsP3) that is required to activate I(CRAC). By increasing the sensitivity of store-operated influx to InsP3, respiring mitochondria will determine whether modest levels of stimulation are capable of evoking Ca2+ entry or not. Mitochondrial Ca2+ buffering therefore increases the dynamic range of concentrations over which the InsP3 is able to function as the physiological messenger that triggers the activation of store-operated Ca2+ influx.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.