Evidence map›Paper›PMID 11387041›Full record

ReviewGenome biology2001

Morpholino antisense oligonucleotides: tools for investigating vertebrate development.

D R Corey, J M Abrams

Open access · bronzeAbstract readReview
In one paragraph

Review in Genome biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 192 citations in OpenAlex.

  1. RNA-Based Therapies for Inherited Metabolic Disorders.Journal of inherited metabolic disease · 2026
    Review
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  9. Genetic requirement ofbioRxiv : the preprint server for biology · 2024
    Article
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  19. An Encodable Scaffold for Sequence-Specific Recognition of Duplex RNA.Angewandte Chemie (International ed. in English) · 2023
    Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

D R CoreyDepartments of Pharmacology and Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA. david.corey@utsouthwestern.edu
J M Abrams
Southwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

MOLECULAR AND GENETIC CONTROL OF PROGRAMMED CELL DEATHR01AG012466 · NIA · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI ABRAMS, JOHN MICHAEL · 1995 to 2003
$1.4M
NIA NIH HHS AG12466NIGMS NIH HHS GM606024
6 · The paper itself

Abstract

Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsMorpholinesOligonucleotides, AntisenseRNA, MessengerSea UrchinsZebrafishMorpholinesOligonucleotides, AntisenseRNA, Messenger

Identifiers

PMID11387041
PMCPMC138935
OpenAlexW2136180305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.