ArticleThe Journal of biological chemistry2001
Myosin ii light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1.
Article in The Journal of biological chemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- MLC2: Physiological Functions and Potential Roles in Tumorigenesis.Cell biochemistry and biophysics · 2025Review
- Frail Silk: Is the Hughes-Stovin Syndrome a Behçet Syndrome Subtype with Aneurysm-Involved Gene Variants?International journal of molecular sciences · 2023Review
- Involvement of the Actin Machinery in Programmed Cell Death.Frontiers in cell and developmental biology · 2020Review
- Spatial Fluctuations at Vertices of Epithelial Layers: Quantification of Regulation by Rho Pathway.Biophysical journal · 2018Article
- Gene silencing NMII promotes axonal regeneration against contusive spinal cord injury in rats.International journal of clinical and experimental pathology · 2017Article
- Par-3 modulates intestinal epithelial barrier function through regulating intracellular trafficking of occludin and myosin light chain phosphorylation.Journal of gastroenterology · 2015Article
- Role of LARP6 and nonmuscle myosin in partitioning of collagen mRNAs to the ER membrane.PloS one · 2014Article
- Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- The actin cytoskeleton as a sensor and mediator of apoptosis.Bioarchitecture · 2012Article
- The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding.Gastroenterology · 2011Article
- Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway.PLoS pathogens · 2011Article
- Cytotoxic Effects on HL-60 Cells of Myosin Light Chain Kinase Inhibitor ML-7 Alone and in Combination with Flavonoids.Toxicological research · 2009Article
- ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK.The Journal of biological chemistry · 2009Article
- GammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk.Journal of virology · 2008Article
- Drosophila Myosin II, Zipper, is essential for ommatidial rotation.Developmental biology · 2007Article
- Plant and animal pathogen recognition receptors signal through non-RD kinases.PLoS pathogens · 2006Article
- Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo.Molecular and cellular biology · 2005Article
- A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling.The Biochemical journal · 2004Article
- Antisense depletion of death-associated protein kinase promotes apoptosis.The Journal of biological chemistry · 2003Article
- Distribution and expression of non-muscle myosin light chain kinase in rabbit livers.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Activation of myosin II by myosin light chain kinase (MLCK) produces the force for many cellular processes including muscle contraction, mitosis, migration, and other cellular shape changes. The results of this study show that inhibition or potentiation of myosin II activation via over-expression of a dominant negative or wild type MLCK can delay or accelerate tumor necrosis factor-alpha (TNF)-induced apoptotic cell death in cells. Changes in the activation of caspase-8 that parallel changes in regulatory light chain phosphorylation levels reveal that myosin II motor activities regulate TNF receptor-1 (TNFR-1) signaling at an early step in the TNF death signaling pathway. Treatment of cells with either ionomycin or endotoxin (lipopolysaccharide) leads to activation of myosin II and increased translocation of TNFR-1 to the plasma membrane independent of TNF signaling. The results of these studies establish a new role for myosin II motor activity in regulating TNFR-1-mediated apoptosis through the translocation of TNFR-1 to or within the plasma membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.