ArticleBritish journal of cancer2001
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 116 citations in OpenAlex.
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- The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model.International journal of cancer · 2018Article
- p53 and metabolism: from mechanism to therapeutics.Oncotarget · 2018Review
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- [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.Molecular imaging and biology · 2016Article
- Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.The Journal of biological chemistry · 2015Article
- Genome-wide analysis of microRNA and mRNA expression signatures in cancer.Acta pharmacologica Sinica · 2015Review
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- Proteomic approaches and identification of novel therapeutic targets for alcoholism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures.Cancer research · 2013Article
- Expression patterns of ubiquitin conjugating enzyme UbcM2 during mouse embryonic development.Gene expression · 2012Article
- Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.Progress in molecular biology and translational science · 2011Review
- LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer.BMC medical genomics · 2010Article
- LSOSS: Detection of Cancer Outlier Differential Gene Expression.Biomarker insights · 2010Article
- High-grade prostatic intraepithelial neoplasia of the prostate: the precursor lesion of prostate cancer.International journal of clinical and experimental pathology · 2009Article
- Biomarkers for benign prostatic hyperplasia progression.Current urology reports · 2008Review
- Aberrant expression of RAB1A in human tongue cancer.British journal of cancer · 2005Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of novel genes or groups of genes expressed in prostate cancer may allow earlier diagnosis or more accurate staging of the disease. We describe the assembly and use of a 1877-member microarray representing cDNA clones from a range of prostate cancer stages and grades, precursor lesions and normal tissue. Using labelled cDNA from tumour samples obtained from TURP or radical prostatectomy, analysis of expression patterns identified many up-regulated transcripts. Cell lines were found to over-express fewer genes than diseased tissue samples. 17 known genes were found to over-express more than 4-fold in 4 or more cancers out of 15 cancers. Only 2 genes were over-expressed in 6 out of 15 cancers or more, whilst no genes were consistently found to be over-expressed in all cancer samples. Novel prostate cancer associations for several well characterized genes or full length cDNAs were identified, including PLRP1, JM27, human UbcM2, dynein light intermediate chain 2 and human homologue of rat sec61. Novel associations with high-grade PIN include: breast carcinoma fatty acid synthase and cDNA DKFZp434B0335. We shortlist and discuss the most significant over-expressed genes in prostate cancer and PIN, and highlight expression differences between malignant and benign samples.
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