ArticleThe Journal of cell biology2001
Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 98 citations in OpenAlex.
- The mitochondrial proteome of diplonemids: from conventional pathways to eccentric RNA editing and transcript processing.BMC genomics · 2025Article
- Protein insertion into the inner membrane of mitochondria: routes and mechanisms.FEBS open bio · 2024Review
- Molecular pathways in mitochondrial disorders due to a defective mitochondrial protein synthesis.Frontiers in cell and developmental biology · 2024Review
- Mitochondrial Membrane-Associated Protein Mba1 Confers Antifungal Resistance by Affecting the Production of Reactive Oxygen Species in Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2023Article
- Targeting and Insertion of Membrane Proteins in Mitochondria.Frontiers in cell and developmental biology · 2021Review
- Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System.Cells · 2018Article
- The ribosome receptors Mrx15 and Mba1 jointly organize cotranslational insertion and protein biogenesis in mitochondria.Molecular biology of the cell · 2018Article
- Identification of Genes inG3 (Bethesda, Md.) · 2017Article
- Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates.Molecular and cellular biology · 2016Article
- Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins.Cell metabolism · 2016Article
- Article
- Arabidopsis thaliana Oxa proteins locate to mitochondria and fulfill essential roles during embryo development.Planta · 2013Article
- Dissecting stop transfer versus conservative sorting pathways for mitochondrial inner membrane proteins in vivo.The Journal of biological chemistry · 2013Article
- Mitochondrial protein synthesis, import, and assembly.Genetics · 2012Article
- Oxa1-ribosome complexes coordinate the assembly of cytochrome C oxidase in mitochondria.The Journal of biological chemistry · 2012Article
- Multiple roles of the Cox20 chaperone in assembly of Saccharomyces cerevisiae cytochrome c oxidase.Genetics · 2012Article
- Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome.The Journal of biological chemistry · 2010Article
- Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation.Molecular biology of the cell · 2010Article
- The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.Molecular and cellular biology · 2010Article
- Mitochondrial translation and beyond: processes implicated in combined oxidative phosphorylation deficiencies.Journal of biomedicine & biotechnology · 2010Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biogenesis of mitochondria requires the integration of many proteins into the inner membrane from the matrix side. The inner membrane protein Oxa1 plays an important role in this process. We identified Mba1 as a second mitochondrial component that is required for efficient protein insertion. Like Oxa1, Mba1 specifically interacts both with mitochondrial translation products and with conservatively sorted, nuclear-encoded proteins during their integration into the inner membrane. Oxa1 and Mba1 overlap in function and substrate specificity, but both can act independently of each other. We conclude that Mba1 is part of the mitochondrial protein export machinery and represents the first component of a novel Oxa1-independent insertion pathway into the mitochondrial inner membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.