ArticleThe Journal of cell biology2001
Growth cone collapse through coincident loss of actin bundles and leading edge actin without actin depolymerization.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion.Frontiers in molecular neuroscience · 2023Article
- Prostaglandin E2 Increases Neurite Length and the Formation of Axonal Loops, and Regulates Cone Turning in Differentiating NE4C Cells Via PKA.Cellular and molecular neurobiology · 2022Article
- Review
- Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2.Developmental neurobiology · 2021Article
- Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment.Cells · 2020Review
- Microtubules: Evolving roles and critical cellular interactions.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Roles of 5-HT on phase transition of neurite outgrowth in the identified serotoninergic neuron C1, Helisoma trivolvis.Invertebrate neuroscience : IN · 2018Article
- Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Calcineurin-dependent cofilin activation and increased retrograde actin flow drive 5-HT-dependent neurite outgrowth in Aplysia bag cell neurons.Molecular biology of the cell · 2012Article
- Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.Molecular and cellular neurosciences · 2012Article
- Communication between 5-HT and small GTPases.Current opinion in pharmacology · 2011Review
- Serotonin: a regulator of neuronal morphology and circuitry.Trends in neurosciences · 2010Review
- Disruption of the cytoskeleton during Semaphorin 3A induced growth cone collapse correlates with differences in actin organization and associated binding proteins.Developmental neurobiology · 2009Article
- Axon extension in the fast and slow lanes: substratum-dependent engagement of myosin II functions.Developmental neurobiology · 2007Article
- Guiding neuronal growth cones using Ca2+ signals.Trends in cell biology · 2004Review
- Netrin-1 and semaphorin 3A promote or inhibit cortical axon branching, respectively, by reorganization of the cytoskeleton.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Microtubule reconfiguration during axonal retraction induced by nitric oxide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Growth cone collapse induced by semaphorin 3A requires 12/15-lipoxygenase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Focal loss of actin bundles causes microtubule redistribution and growth cone turning.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Repulsive guidance cues can either collapse the whole growth cone to arrest neurite outgrowth or cause asymmetric collapse leading to growth cone turning. How signals from repulsive cues are translated by growth cones into this morphological change through rearranging the cytoskeleton is unclear. We examined three factors that are able to induce the collapse of extending Helisoma growth cones in conditioned medium, including serotonin, myosin light chain kinase inhibitor, and phorbol ester. To study the cytoskeletal events contributing to collapse, we cultured Helisoma growth cones on polylysine in which lamellipodial collapse was prevented by substrate adhesion. We found that all three factors that induced collapse of extending growth cones also caused actin bundle loss in polylysine-attached growth cones without loss of actin meshwork. In addition, actin bundle loss correlated with specific filamentous actin redistribution away from the leading edge that is characteristic of repulsive factors. Finally, we provide direct evidence using time-lapse studies of extending growth cones that actin bundle loss paralleled collapse. Taken together, these results suggest that actin bundles could be a common cytoskeletal target of various collapsing factors, which may use different signaling pathways that converge to induce growth cone collapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.