ArticleThe Journal of cell biology2001
Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- The Association of p27 With Prostate Cancer Outcomes: A Secondary Analysis of NRG/RTOG 8610 and 9202.Advances in radiation oncology · 2026Article
- Effects of seasonal ambient heat stress on expression of microRNAs in the mammary gland of Holstein cows.International journal of biometeorology · 2021Article
- CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer.The Journal of pathology · 2021Article
- Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.PLoS genetics · 2019Article
- Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation.Oncotarget · 2016Article
- Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins.Scientific reports · 2016Article
- Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.Cell stem cell · 2013Article
- A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1.Cancer cell · 2013Article
- Hunk is required for HER2/neu-induced mammary tumorigenesis.The Journal of clinical investigation · 2011Article
- Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation.BMC developmental biology · 2010Article
- ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.Molecular and cellular biology · 2009Article
- A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development.Molecular and cellular biology · 2009Article
- Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis.Cell proliferation · 2007Article
- Regulation of CDK4.Cell division · 2006Article
- Pubertal mammary gland development: insights from mouse models.Journal of mammary gland biology and neoplasia · 2006Review
- Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".Molecular and cellular biology · 2006Article
- Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression.Oncogene · 2006Article
- Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2.Molecular and cellular biology · 2006Article
- Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner.Oncogene · 2005Article
- A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We have studied the role of the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) in postnatal mammary gland morphogenesis. Based on its ability to negatively regulate cyclin/Cdk function, loss of p27 may result in unrestrained cellular proliferation. However, recent evidence about the stabilizing effect of p27 on cyclin D1-Cdk4 complexes suggests that p27 deficiency might recapitulate the hypoplastic mammary phenotype of cyclin D1-deficient animals. These hypotheses were investigated in postnatal p27-deficient (p27(-/-)), hemizygous (p27(+/)-), or wild-type (p27(+/+)) mammary glands. Mammary glands from p27(+/)- mice displayed increased ductal branching and proliferation with delayed postlactational involution. In contrast, p27(-/-) mammary glands or wild-type mammary fat pads reconstituted with p27(-/-) epithelium produced the opposite phenotype: hypoplasia, low proliferation, decreased ductal branching, impaired lobuloalveolar differentiation, and inability to lactate. The association of cyclin D1 with Cdk4, the kinase activity of Cdk4 against pRb in vitro, the nuclear localization of cyclin D1, and the stability of cyclin D1 were all severely impaired in p27(-/-) mammary epithelial cells compared with p27(+/+) and p27(+/-) mammary epithelial cells. Therefore, p27 is required for mammary gland development in a dose-dependent fashion and positively regulates cyclin D-Cdk4 function in the mammary gland.
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