ArticleNucleic acids research2001
Identification of a putative chromosomal replication origin from Helicobacter pylori and its interaction with the initiator protein DnaA.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Computational prediction of replication origins: a comparative review of methods, benchmarks, and trends from heuristics to deep learning.Briefings in bioinformatics · 2026Review
- Evidence for a chromosome origin unwinding system broadly conserved in bacteria.Nucleic acids research · 2021Article
- Transcription-Associated Compositional Skews in Drosophila Genes.Genome biology and evolution · 2018Article
- Review
- Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence.Microbiology (Reading, England) · 2016Article
- 'Modulation of the enzymatic activities of replicative helicase (DnaB) by interaction with Hp0897: a possible mechanism for helicase loading in Helicobacter pylori'.Nucleic acids research · 2016Article
- Unique and Universal Features of Epsilonproteobacterial Origins of Chromosome Replication and DnaA-DnaA Box Interactions.Frontiers in microbiology · 2016Article
- Initiation of Chromosomal Replication in Predatory BacteriumFrontiers in microbiology · 2016Article
- oriC-encoded instructions for the initiation of bacterial chromosome replication.Frontiers in microbiology · 2014Review
- Chromosomal replication initiation machinery of low-G+C-content Firmicutes.Journal of bacteriology · 2012Review
- Helicobacter pylori oriC--the first bipartite origin of chromosome replication in Gram-negative bacteria.Nucleic acids research · 2012Article
- Structural insight into Helicobacter pylori DNA replication initiation.Gut microbes · 2010Article
- The structure of a DnaA/HobA complex from Helicobacter pylori provides insight into regulation of DNA replication in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth.BMC genomics · 2008Article
- Separating the effects of mutation and selection in producing DNA skew in bacterial chromosomes.BMC genomics · 2007Article
- The GC skew index: a measure of genomic compositional asymmetry and the degree of replicational selection.Evolutionary bioinformatics online · 2007Article
- Helicobacter pylori DnaB helicase can bypass Escherichia coli DnaC function in vivo.The Biochemical journal · 2005Article
- Architecture of bacterial replication initiation complexes: orisomes from four unrelated bacteria.The Biochemical journal · 2005Article
- Where does bacterial replication start? Rules for predicting the oriC region.Nucleic acids research · 2004Article
- Functional characterization of Helicobacter pylori DnaB helicase.Nucleic acids research · 2003Article
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Authors and funding
8 authors.
Funding
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Abstract
The key elements of the initiation of Helicobacter pylori chromosome replication, DnaA protein and putative oriC region, have been characterized. The gene arrangement in the H.pylori dnaA region differs from that found in many other eubacterial dnaA regions (rnpA-rmpH-dnaA-dnaN-recF-gyrB). Helicobacter pylori dnaA is flanked by two open reading frames with unknown function, while dnaN-gyrB and rnpA-rmpH loci are separated from the dnaA gene by 600 and 90 kb, respectively. We show that the dnaA gene encoding initiator protein DnaA is expressed in H.pylori cells. The H.pylori DnaA protein, like other DnaA proteins, can be divided into four domains. Here we demonstrate that the C-terminal domain of H.pylori DnaA protein is responsible for DNA binding. Using in silico and in vitro studies, the putative oriC region containing five DnaA boxes has been located upstream of the dnaA gene. DNase I and gel retardation analyses show that the C-terminal domain of H.pylori DnaA protein specifically binds each of five DnaA boxes.
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