ArticleThe Journal of clinical investigation2001
Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 180 citations in OpenAlex.
- The Role of Extracellular Vesicles in Bone Regeneration and Associated Bone Diseases.Current issues in molecular biology · 2024Review
- Non-radioactive imaging strategies forPhysical sciences reviews · 2023Article
- Immunopathological Analysis of a Mouse Model of Arthritis-Associated Scleritis and Implications for Molecular Targeted Therapy for Severe Scleritis.International journal of molecular sciences · 2021Article
- Insights Into Leukocyte Trafficking in Inflammatory Arthritis - Imaging the Joint.Frontiers in cell and developmental biology · 2021Review
- Virus-based nanoparticles as platform technologies for modern vaccines.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules.BMB reports · 2016Article
- Versatility of using major histocompatibility complex class II dextramers for derivation and characterization of antigen-specific, autoreactive T cell hybridomas.Journal of immunological methods · 2015Article
- IL-12p40 Homodimer Ameliorates Experimental Autoimmune Arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Imaging evaluation of inflammation in the musculoskeletal system: current concepts and perspectives.Skeletal radiology · 2013Review
- Subcutaneous administration of D-luciferin is an effective alternative to intraperitoneal injection in bioluminescence imaging of xenograft tumors in nude mice.ISRN Molecular Imaging · 2013Article
- In vivo Noninvasive Small Animal Molecular Imaging.Osong public health and research perspectives · 2012Review
- Immunosuppressive exosomes: a new approach for treating arthritis.International journal of rheumatology · 2012Article
- A window on disease pathogenesis and potential therapeutic strategies: molecular imaging for arthritis.Arthritis research & therapy · 2011Review
- Optical imaging: new tools for arthritis.Integrative biology : quantitative biosciences from nano to macro · 2010Review
- The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis.Experimental & molecular medicine · 2010Article
- Epithelial uptake of [18F]1-(2'-deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice.Gastroenterology · 2010Article
- TGF-beta-treated antigen presenting cells suppress collagen- induced arthritis through the promotion of Th2 responses.Experimental & molecular medicine · 2010Article
- Musculoskeletal molecular imaging: a comprehensive overview.Trends in biotechnology · 2010Review
- An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritis.Optics express · 2009Article
- The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses.Immunology · 2009Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
Autoantigen-specific T cells have tissue-specific homing properties, suggesting that these cells may be ideal vehicles for the local delivery of immunoregulatory molecules. We tested this hypothesis by using type II collagen-specific (CII-specific) CD4(+) T hybridomas or primary CD4(+) T cells after gene transfer, as vehicles to deliver an immunoregulatory protein for the treatment of collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). CII-specific T cells or hybridomas were transduced using retroviral vectors to constitutively express the IL-12 antagonist, IL-12 p40. Transfer of engineered CD4(+) T cells after immunization significantly inhibited the development of CIA, while cells transduced with vector control had no effect. The beneficial effect on CIA of IL-12 p40-transduced T cells required TCR specificity against CII, since transfer of T cells specific for another antigen producing equivalent amounts of IL-12 p40 had no effect. In vivo cell detection using bioluminescent labels and RT-PCR showed that transferred CII-reactive T-cell hybridomas accumulated in inflamed joints in mice with CIA. These results indicate that the local delivery of IL-12 p40 by T cells inhibited CIA by suppressing autoimmune responses at the site of inflammation. Modifying antigen-specific T cells by retroviral transduction for local expression of immunoregulatory proteins thus offers a promising strategy for treating RA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.