ReviewInternational journal of hematology2001
New clinical applications of xanthine derivatives: modulatory actions on leukocyte survival and function.
Review in International journal of hematology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Generation of Immune Modulating Small Metabolites-Metabokines-By Adult Schistosomes.Pathogens (Basel, Switzerland) · 2025Article
- Synthetic riboswitches for the analysis of tRNA processing by eukaryotic RNase P enzymes.RNA (New York, N.Y.) · 2022Article
- Effects of Helioxanthin Derivative-Treated Human Dental Pulp Stem Cells on Fracture Healing.International journal of molecular sciences · 2020Article
- An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts.Regenerative therapy · 2019Article
- Methylxanthine use for acute asthma in the emergency department in Japan: a multicenter observational study.Acute medicine & surgery · 2019Article
- An ab initio and AIM investigation into the hydration of 2-thioxanthine.Chemistry Central journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of theophylline in the treatment of obstructive pulmonary diseases has diminished with the advent of new medications. However, its use as a second-line bronchodilator has been reconsidered in recent years. Theophylline is reported to have immunomodulatory actions that may account for its clinical effectiveness in the control of airway inflammation. Theophylline, even at low plasma concentrations, inhibits the late asthmatic reaction following allergen challenge. The apparent suppression of airway inflammation by theophylline reinforces findings from in vitro experiments (including our recent studies). Its immunomodulatory actions include inhibition of cytokine synthesis and release, inhibition of inflammatory cell activation, and acceleration of granulocyte apoptosis. On the basis of these findings, theophylline has been re-evaluated as a key drug for the long-term management of bronchial asthma, and new applications are proposed for the clinical use of xanthine derivatives. Here, we review some recent advances in the understanding of pharmacological actions and new applications of xanthine derivatives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.