ReviewInstructional course lectures2001
The basic science of periprosthetic osteolysis.
Review in Instructional course lectures, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- The John Charnley Award: Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal total hip arthroplasty: a randomized clinical trial.Clinical orthopaedics and related research · 2010Trial
- Chemical, Mechanical and Tribological Effects of Artificially Aging up to 6 Weeks on Virgin and Crosslinked UHMWPE Evaluated for a TKR Design.Bioengineering (Basel, Switzerland) · 2025Article
- Adverse Local Tissue Reaction and Osteolysis After Ceramic-on-Ceramic Total Hip Arthroplasty.Arthroplasty today · 2024Article
- Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty.BMC musculoskeletal disorders · 2023Article
- The Utility of Isotropic 3D Magnetic Resonance Imaging in Assessing Painful Total Ankle Replacements.Foot & ankle orthopaedics · 2022Review
- Characteristics of Particles and Debris Released after Implantoplasty: A Comparative Study.Materials (Basel, Switzerland) · 2022Article
- Additive Effect of Parathyroid Hormone and Zoledronate Acid on Prevention Particle Wears-Induced Implant Loosening by Promoting Periprosthetic Bone Architecture and Strength in an Ovariectomized Rat Model.Frontiers in endocrinology · 2022Article
- Third-Generation Medium Cross-Linked Polyethylene Demonstrates Very Low Wear in Total Hip Arthroplasty.Arthroplasty today · 2020Article
- Influence of single nucleotide polymorphisms (SNPs) in genetic susceptibility towards periprosthetic osteolysis.Genes & genomics · 2019Review
- The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants.Aesthetic surgery journal · 2019Review
- Periprosthetic metastasis following total hip arthroplasty in a patient with lung carcinoma: A case report and review of literature.Medicine · 2019Review
- Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.BioResearch open access · 2017Review
- Long-term durability of alumina ceramic heads in THA.BMC musculoskeletal disorders · 2015Article
- Article
- Bearing surfaces in hip replacement - Evolution and likely future.Medical journal, Armed Forces India · 2014Review
- Nanostructured diamond coatings for orthopaedic applications.Woodhead publishing series in biomaterials · 2013Article
- Blockade of JNK and NFAT pathways attenuates orthopedic particle-stimulated osteoclastogenesis of human osteoclast precursors and murine calvarial osteolysis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- Exogenous MC3T3 preosteoblasts migrate systemically and mitigate the adverse effects of wear particles.Tissue engineering. Part A · 2012Article
- Periprosthetic osteolysis: genetics, mechanisms and potential therapeutic interventions.Canadian journal of surgery. Journal canadien de chirurgie · 2012Review
- Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss.Biomaterials · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Despite improvements in the techniques, materials, and fixation of total joint replacements, wear and its sequelae continue to be the main factors limiting the longevity and clinical success of arthroplasty. Since Charnley first recognized aseptic loosening in the early 1960s, a tremendous amount of information has been gained on the basic science of osteolysis. Tissue explant, animal, and cell culture studies have allowed development of an appreciation of the complexity of cellular interactions and chemical mediators involved in these processes. Cellular participants have been shown to include the macrophage, osteoblast, fibroblast, and osteoclast. The plethora of chemical mediators that are responsible for the cellular interactions and effects on bone primarily include PGE2, TNF-alpha, IL-1, and IL-6. Recent and ongoing work in the field of signaling pathways will continue to advance our understanding of the mechanisms of periprosthetic bone loss. Although initial animal studies are promising for the development of possible pharmacologic agents for the treatment and prevention of osteolysis, well controlled human trials are required.
Indexed as
Identifiers
11372314What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.