Trial reportAnnals of surgery2001
Attenuation of posttraumatic muscle catabolism and osteopenia by long-term growth hormone therapy.
Trial report in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Recombinant human growth hormone for treating burns and donor sites.The Cochrane database of systematic reviews · 2014Pooled it
- Trial
- Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children.Annals of surgery · 2009Trial
- Trial
- The effects of oxandrolone and exercise on muscle mass and function in children with severe burns.Pediatrics · 2007Trial
- Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients.Annals of surgery · 2006Trial
- The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Trial
- Beta-blockade and growth hormone after burn.Annals of surgery · 2002Trial
- Persistent inflammation, immunosuppression, and catabolism syndrome and sepsis in pediatric burns.Burns : journal of the International Society for Burn Injuries · 2025Article
- Pathophysiology and Therapeutic Management of Bone Loss in Patients with Critical Illness.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Children's growth and motor development following a severe burn: a systematic review.Burns & trauma · 2023Article
- A Pilot Study To Compare Nutrition Screening Tools: Customized Nutrition Screening Tool for Burn Patients (Nstb) and Malnutrition Universal Screening Tool (Must).Annals of burns and fire disasters · 2022Article
- Chronic Critical Illness and PICS Nutritional Strategies.Journal of clinical medicine · 2021Review
- Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.Burns : journal of the International Society for Burn Injuries · 2020Review
- The Long-Term Impact of Severe Burn Trauma on Musculoskeletal Health.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- The Role of Bone Secreted Factors in Burn-Induced Muscle Cachexia.Current osteoporosis reports · 2018Review
- Chronic Critical Illness: Application of What We Know.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2018Review
- The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- Burn injury: review of pathophysiology and therapeutic modalities in major burns.Annals of burns and fire disasters · 2017Article
- The calcium-sensing receptor as a mediator of inflammation.Seminars in cell & developmental biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether the beneficial effects of growth hormone persist throughout the prolonged hypermetabolic and hypercatabolic response to severe burn. SUMMARY BACKGROUND DATA: The hypermetabolic response to severe burn is associated with increased energy expenditure, insulin resistance, immunodeficiency, and whole body catabolism that persists for months after injury. Growth hormone is a potent anabolic agent and salutary modulator of posttraumatic metabolic responses.
methodsSeventy-two severely burned children were enrolled in a placebo-controlled double-blind trial investigating the effects of growth hormone (0.05 mg/kg per day) on muscle accretion and bone growth. Drug or placebo treatment began on discharge from the intensive care unit and continued for 1 year after burn. Total body weight, height, dual-energy x-ray absorptiometry, indirect calorimetry, and hormone values were measured at discharge, then at 6 months, 9 months, and 12 months after burn. Results were compared between groups.
resultsGrowth hormone subjects gained more weight than placebo subjects at the 9-month study point; this disparity in weight gain continued to expand throughout the remainder of the study. Height also increased in the growth hormone group compared with controls at 12 months. Change in lean body mass was greater in those treated with growth hormone at 6, 9, and 12 months. Bone mineral content was increased at 9 and 12 months; this was associated with higher parathormone levels.
conclusionsLow-dose recombinant human growth hormone successfully abates muscle catabolism and osteopenia induced by severe burn.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.