ArticleProceedings of the National Academy of Sciences of the United States of America2001
Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Modulating PAK1: Accessory Proteins as Promising Therapeutic Targets.Biomolecules · 2025Review
- p21-Activated Kinases in Thyroid Cancer.Endocrinology · 2020Review
- A High-Resolution Proteomic Landscaping of Primary Human Dental Stem Cells: Identification of SHED- and PDLSC-Specific Biomarkers.International journal of molecular sciences · 2018Article
- β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation.World journal of gastroenterology · 2015Article
- Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.Advances in experimental medicine and biology · 2015Review
- Sodium methyldithiocarbamate exerts broad inhibition of cellular signaling and expression of effector molecules of inflammation.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Article
- PAK family kinases: Physiological roles and regulation.Cellular logistics · 2012Article
- Characterization and comparison of the leukocyte transcriptomes of three cattle breeds.PloS one · 2012Article
- PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop.Nucleic acids research · 2011Article
- PAK1 as a therapeutic target.Expert opinion on therapeutic targets · 2010Review
- Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells.Circulation research · 2010Article
- Pak protein kinases and their role in cancer.Cancer metastasis reviews · 2009Review
- PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.The Journal of biological chemistry · 2008Article
- An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.Chemistry & biology · 2008Article
- Roles of P21-activated kinases and associated proteins in epithelial wound healing.International review of cell and molecular biology · 2008Review
- Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro.Molecular biology of the cell · 2007Article
- The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors.Molecular and cellular biology · 2007Article
- Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.The Journal of cell biology · 2007Article
- CRIPak, a novel endogenous Pak1 inhibitor.Oncogene · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The family of p21-activated protein kinases (PAKs) is composed of serine-threonine kinases whose activity is regulated by the small guanosine triphosphatases (GTPases) Rac and Cdc42. In mammalian cells, PAKs have been implicated in the regulation of mitogen-activated protein cascades, cellular morphological and cytoskeletal changes, neurite outgrowth, and cell apoptosis. Although the ability of Cdc42 and Rac GTPases to activate PAK is well established, relatively little is known about the negative regulation of PAK or the identity of PAK cellular targets. Here, we describe the identification and characterization of a human PAK-interacting protein, hPIP1. hPIP1 contains G protein beta-like WD repeats and shares sequence homology with the essential fission yeast PAK regulator, Skb15, as well as the essential budding yeast protein, MAK11. Interaction of hPIP1 with PAK1 inhibits the Cdc42/Rac-stimulated kinase activity through the N-terminal regulatory domains of PAK1. Cotransfection of hPIP1 in mammalian cells inhibits PAK-mediated c-Jun N-terminal kinase and nuclear factor kappa B signaling pathways. Our results demonstrate that hPIP1 is a negative regulator of PAK and PAK signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.