ArticleProceedings of the National Academy of Sciences of the United States of America2001
Unexpected signals in a system subject to kinetic proofreading.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Regulation of IgE by T follicular helper cells.Journal of leukocyte biology · 2020Review
- Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription.Cellular immunology · 2017Article
- Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics.Molecular biology of the cell · 2017Article
- Simple biochemical networks allow accurate sensing of multiple ligands with a single receptor.PLoS computational biology · 2017Article
- Article
- Rethinking the role of immunoglobulin E and its high-affinity receptor: new insights into allergy and beyond.International archives of allergy and immunology · 2014Review
- Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.The Journal of clinical investigation · 2005Article
- IgE and FcepsilonRI regulation.Clinical reviews in allergy & immunology · 2005Review
- Article
- Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.The Journal of experimental medicine · 2003Article
- Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis.Molecular and cellular biology · 2003Article
- Signaling cascades: escape from kinetic proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Dependence of Optimal Histamine Release on Cell Surface IgE Density on Human Basophils: Nature of the Stimulus.International archives of allergy and immunologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
When multivalent ligands attach to IgEs bound to the receptors with high affinity for IgE on mast cells, the receptors aggregate, tyrosines on the receptors become phosphorylated, and a variety of cellular responses are stimulated. Prior studies, confirmed here, demonstrated that the efficiency with which later events are generated from earlier ones is inversely related to the dissociation rate of the aggregating ligand. This finding suggests that the cellular responses are constrained by a "kinetic proofreading" regimen. We have now observed an apparent exception to this rule. Doses of the rapidly or slowly dissociating ligands that generated equivalent levels of tyrosine-phosphorylated receptors comparably stimulated a putatively distal event: transcription of the gene for monocyte chemoattractant protein 1. Possible explanations of this apparent anomaly were explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.