ArticleJournal of bacteriology2001
Transcriptional pattern of genes coding for the proteolytic system of Lactococcus lactis and evidence for coordinated regulation of key enzymes by peptide supply.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 132 citations in OpenAlex.
- Comparative analysis of proteolytic activity in lactic and propionic acid bacteria: substrate specificity and complementary effects in dairy fermentation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Functional Characterization of DifferentFoods (Basel, Switzerland) · 2024Article
- A Novel Regulator PepR Regulates the Expression of Dipeptidase GeneMicroorganisms · 2024Article
- Comprehensive characterization of γ-aminobutyric acid (GABA) production byFrontiers in microbiology · 2024Article
- Molecular and biotechnological characteristics of proteolytic activity fromAIMS microbiology · 2023Article
- The Enzyme Gene Expression of Protein Utilization and Metabolism byMicroorganisms · 2022Article
- Mixed dairy and plant-based yogurt alternatives: Improving their physical and sensorial properties through formulation and lactic acid bacteria cocultures.Current research in food science · 2022Article
- Characteristics of the Proteolytic Enzymes Produced by Lactic Acid Bacteria.Molecules (Basel, Switzerland) · 2021Review
- Positive Interactions Between Lactic Acid Bacteria Could Be Mediated by Peptides Containing Branched-Chain Amino Acids.Frontiers in microbiology · 2021Article
- Integrated Transcriptome and Proteome Analyses Reveal Protein Metabolism inFrontiers in microbiology · 2021Article
- Editing of the Proteolytic System of Lactococcus lactis Increases Its Bioactive Potential.Applied and environmental microbiology · 2020Article
- Insight into the bovine milk peptide LPcin-YK3 selection in the proteolytic system of Lactobacillus species.Journal of peptide science : an official publication of the European Peptide Society · 2020Article
- YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus.Scientific reports · 2017Article
- Comparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptation.BMC genomics · 2017Article
- Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2016Article
- Effect of culturing conditions on the expression of key enzymes in the proteolytic system of Lactobacillus bulgaricus.Journal of Zhejiang University. Science. B · 2015Article
- Transcriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk.Journal of industrial microbiology & biotechnology · 2012Article
- Three paralogous LysR-type transcriptional regulators control sulfur amino acid supply in Streptococcus mutans.Journal of bacteriology · 2010Article
- Transcriptome analysis of the phytobacterium Xylella fastidiosa growing under xylem-based chemical conditions.Journal of biomedicine & biotechnology · 2010Article
- Regulatory phenotyping reveals important diversity within the species Lactococcus lactis.Applied and environmental microbiology · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription of 16 genes encoding 12 peptidases (pepC, pepN, pepX, pepP, pepA, pepF2, pepDA1, pepDA2, pepQ, pepT, pepM, and pepO1), P(I) and P(III) proteinases (prtP1 and prtP3), and three transport systems (dtpT, dtpP, and opp-pepO1) of Lactococcus lactis MG1363 was analyzed in response to different environmental factors. Promoter fusions with luciferase reporter genes and/or mRNA analysis were used to study the effects of sugar sources, growth at 37 degrees C, and peptide supply on the transcription of these genes. Only transcription of the pepP gene is modulated by the source of sugar. The presence of potential catabolite-responsive element (CRE) boxes in its promoter region suggests that expression of this gene is directly controlled by catabolic repression. Elevated temperature had no significant effect on the level of transcription of these genes. prtP1, prtP3, pepC, pepN, pepX, and the opp-pepO1 operon are the most highly expressed genes in chemically defined medium, and their expression is repressed 5- to 150-fold by addition of peptide sources such as Casitone in the medium. Moreover, the transcription of prtP1, prtP3, pepC, pepN, and the opp-pepO1 operon is repressed two- to eight-fold by the dipeptides leucylproline and prolylleucine. The transcription of pepDA2 might also be repressed by the peptide sources, but this effect is not observed on the regulation of dtpT, pepP, pepA, pepF2, pepDA1, pepQ, pepT, pepM, and the dtpP operon. The significance of these results with respect to the functions of different components of the proteolytic system in L. lactis are discussed.
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