ArticleJournal of bacteriology2001
Cloning and analysis of a Candida albicans gene that affects cell surface hydrophobicity.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- Acid-Mediated Antimicrobial Activity and Probiotic Potential of an SKS1-knockout Saccharomyces Cerevisiae Strain.Probiotics and antimicrobial proteins · 2026Article
- Salivary proteins modulate Candida albicans virulence and may prevent oropharingeal candidiasis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Mechanistic insights into antifungal potential of Alexidine dihydrochloride and hexachlorophene in Candida albicans: a drug repurposing approach.Archives of microbiology · 2024Article
- Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain?iScience · 2022Review
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis.Frontiers in microbiology · 2021Review
- Role of Cell Surface Hydrophobicity in the Pathogenesis of Medically-Significant Fungi.Frontiers in cellular and infection microbiology · 2020Review
- Candida albicans Biofilm Development and Its Genetic Control.Microbiology spectrum · 2015Article
- Identification of infection- and defense-related genes via a dynamic host-pathogen interaction network using a Candida albicans-zebrafish infection model.Journal of innate immunity · 2013Article
- Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1.Molecular microbiology · 2012Article
- Capric acid secreted by S. boulardii inhibits C. albicans filamentous growth, adhesion and biofilm formation.PloS one · 2010Article
- Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents.Antimicrobial agents and chemotherapy · 2010Article
- Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans.PLoS pathogens · 2009Article
- Proteomic analysis of Mrr1p- and Tac1p-associated differential protein expression in azole-resistant clinical isolates of Candida albicans.Proteomics. Clinical applications · 2009Article
- A Candida albicans early stage biofilm detachment event in rich medium.BMC microbiology · 2009Article
- Candida albicans cell wall proteins.Microbiology and molecular biology reviews : MMBR · 2008Review
- Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.Infection and immunity · 2005Article
- Surface hydrophobicity changes of two Candida albicans serotype B mnn4delta mutants.Eukaryotic cell · 2005Article
- cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol.Antimicrobial agents and chemotherapy · 2005Article
- Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The opportunistic pathogenic yeast Candida albicans exhibits growth phase-dependent changes in cell surface hydrophobicity, which has been correlated with adhesion to host tissues. Cell wall proteins that might contribute to the cell surface hydrophobicity phenotype were released by limited glucanase digestion. These proteins were initially characterized by their rates of retention during hydrophobic interaction chromatography--high-performance liquid chromatography and used as immunogens for monoclonal antibody production. The present work describes the cloning and functional analysis of a C. albicans gene encoding a 38-kDa protein recognized by the monoclonal antibody 6C5-H4CA. The 6C5-H4CA antigen was resolved by two-dimensional electrophoresis, and a partial protein sequence was determined by mass spectrometry analysis of tryptic fragments. The obtained peptides were used to identify the gene sequence from the unannotated C. albicans DNA database. The antibody epitope was provisionally mapped by peptide display panning, and a peptide sequence matching the epitope was identified in the gene sequence. The gene sequence encodes a novel open reading frame (ORF) of unknown function that is highly similar to several other C. albicans ORFs and to a single Saccharomyces cerevisiae ORF. Knockout of the gene resulted in a decrease in measurable cell surface hydrophobicity and in adhesion of C. albicans to fibronectin. The results suggest that the 38-kDa protein is a hydrophobic surface protein that meditates binding to host target proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.