ArticleBiophysical journal2001
A dynamical model of kinesin-microtubule motility assays.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Active spiralling of microtubules driven by kinesin motors.Scientific reports · 2025Article
- De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Linking path and filament persistence lengths of microtubules gliding over kinesin.Scientific reports · 2022Article
- Buckling instabilities and spatio-temporal dynamics of active elastic filaments.Journal of the Royal Society, Interface · 2020Article
- Kinesin motor density and dynamics in gliding microtubule motility.Scientific reports · 2019Article
- Kinesin and Dynein Mechanics: Measurement Methods and Research Applications.Journal of biomechanical engineering · 2018Review
- Embedding dual function into molecular motors through collective motion.Scientific reports · 2017Article
- Automated Multi-Peak Tracking Kymography (AMTraK): A Tool to Quantify Sub-Cellular Dynamics with Sub-Pixel Accuracy.PloS one · 2016Article
- A nonequilibrium power balance relation for analyzing dissipative filament dynamics.The European physical journal. E, Soft matter · 2015Article
- Force-velocity relationship for multiple kinesin motors pulling a magnetic bead.European biophysics journal : EBJ · 2011Article
- Analysis of video-based microscopic particle trajectories using Kalman filtering.Biophysical journal · 2010Article
- Kinesin velocity increases with the number of motors pulling against viscoelastic drag.European biophysics journal : EBJ · 2010Article
- Twirling motion of actin filaments in gliding assays with nonprocessive Myosin motors.Biophysical journal · 2009Article
- Biophysical model of self-organized spindle formation patterns without centrosomes and kinetochores.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Fast vesicle transport in PC12 neurites: velocities and forces.European biophysics journal : EBJ · 2004Article
- Computer simulations reveal motor properties generating stable antiparallel microtubule interactions.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A two-dimensional stochastic model for the dynamics of microtubules in gliding-assay experiments is presented here, which includes the viscous drag acting on the moving fiber and the interaction with the kinesins. For this purpose, we model kinesin as a spring, and explicitly use parameter values to characterize the model from experimental data. We numerically compute the mean attachment lifetimes of all motors, the total force exerted on the microtubules at all times, the effects of a distribution in the motor speeds, and also the mean velocity of a microtubule in a gliding assay. We find quantitative agreement with the results of J. Howard, A. J. Hudspeth, and R. D. Vale, Nature. 342:154-158. We perform additional numerical analysis of the individual motors, and show how cancellation of the forces exerted by the many motors creates a resultant longitudinal force much smaller than the maximum force that could be exerted by a single motor. We also examine the effects of inhomogeneities in the motor-speeds. Finally, we present a simple theoretical model for microtubules dynamics in gliding assays. We show that the model can be analytically solved in the limit of few motors attached to the microtubule and in the opposite limit of high motor density. We find that the speed of the microtubule goes like the mean speed of the motors in good quantitative agreement with the experimental and numerical results.
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