ArticleArchives of disease in childhood2001
Response to influenza immunisation during treatment for cancer.
Article in Archives of disease in childhood, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Influenza vaccination in children being treated with chemotherapy for cancer.The Cochrane database of systematic reviews · 2013Pooled it
- Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective.PloS one · 2011Pooled it
- Trial
- Safety of high dose trivalent inactivated influenza vaccine in pediatric patients with acute lymphoblastic leukemia.Pediatric blood & cancer · 2014Trial
- Trial
- Influenza-associated morbidity in children with cancer.Pediatric blood & cancer · 2008Trial
- Immune response to influenza vaccination in children with cancer.Human vaccines & immunotherapeutics · 2018Article
- The Effectiveness of Trivalent Inactivated Influenza Vaccine in Children with Acute Leukemia.The Journal of pediatrics · 2017Observational
- Immunogenicity and clinical effectiveness of the trivalent inactivated influenza vaccine in immunocompromised children undergoing treatment for cancer.Cancer medicine · 2016Article
- Guidelines on vaccinations in paediatric haematology and oncology patients.BioMed research international · 2014Review
- Immunogenicity of influenza vaccine in colorectal cancer patients.Cancer research and treatment · 2013Article
- A prospective study of chemotherapy immunologic effects and predictors of humoral influenza vaccine responses in a pediatric oncology cohort.Influenza and other respiratory viruses · 2013Article
- Protecting pediatric oncology patients from influenza.The oncologist · 2013Review
- Absolute lymphocyte count predicts the response to new influenza virus H1N1 vaccination in pediatric cancer patients.Clinical and vaccine immunology : CVI · 2013Article
- Influenza vaccine.Archives of disease in childhood · 2003Article
- Activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs) by human dendritic cells infected with an attenuated influenza A virus expressing a CTL epitope derived from the HER-2/neu proto-oncogene.Journal of virology · 2003Article
- Cancer patients undergoing chemotherapy show adequate serological response to vaccinations against influenza virus and Streptococcus pneumoniae.Medical oncology (Northwood, London, England) · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess the annual risk of influenza infection in children with cancer and the immunogenicity of a trivalent split virus influenza vaccine in these children.
methodsEighty four children with cancer were tested for susceptibility to the circulating strains of influenza virus in autumn 1995 and 1996. Non-immunised children were reassessed the following spring for serological evidence of natural infection. Forty two patients received two doses of influenza vaccine. These children were receiving continuing chemotherapy for acute lymphoblastic leukaemia or were within six months of completing chemotherapy.
resultsAmong the 84 children tested for influenza virus susceptibility only 8% of patients were fully protected (antibody titres >/= 40) against all three of the prevalent influenza virus strains; 33% were susceptible to all three viruses. Evidence of acquired natural infection was seen in 30% of unimmunised patients. Among immunised susceptible patients, 66% made some protective response to the vaccine and 55% showed protective antibody titres to all three viral strains following vaccination. Older age was associated with increased response to the H1N1 and H3N2 vaccine components, but total white cell count or neutrophil count at immunisation, type of cancer, or length of time on treatment for acute lymphoblastic leukaemia did not affect response.
conclusionsMost children with cancer studied were at risk of influenza infection. A significant response to immunisation was seen, supporting annual influenza vaccination for children being treated for cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.