ArticleCurrent biology : CB2001
The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis.
Article in Current biology : CB, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 144 citations in OpenAlex.
- Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II.The Journal of cell biology · 2026Article
- Analysis of nondegradable cyclins reveals distinct roles of the mitotic cyclins in Drosophila meiosis.G3 (Bethesda, Md.) · 2024Article
- The molecular mechanisms of human separase regulation.Biochemical Society transactions · 2023Review
- A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis.Plant direct · 2023Article
- Circadian clock core component Bmal1 dictates cell cycle rhythm of proliferating hepatocytes during liver regeneration.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- A 'dynamic adder model' for cell size homeostasis in Dictyostelium cells.Scientific reports · 2021Article
- Cell cycle control during early embryogenesis.Development (Cambridge, England) · 2021Article
- RNA Helicases as Shadow Modulators of Cell Cycle Progression.International journal of molecular sciences · 2021Review
- Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.PLoS genetics · 2020Article
- Topoisomerase IIα is essential for maintenance of mitotic chromosome structure.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I.The Journal of cell biology · 2019Article
- Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.Journal of experimental & clinical cancer research : CR · 2019Article
- Calcineurin-dependent Protein Phosphorylation Changes During Egg Activation inMolecular & cellular proteomics : MCP · 2019Article
- Condensin recruitment to chromatin is inhibited by Chk2 kinase in response to DNA damage.Cell cycle (Georgetown, Tex.) · 2016Article
- Anaphase B.Biology · 2016Review
- Review
- Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.Current biology : CB · 2015Article
- Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regeneration.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Measuring protein stability in living zebrafish embryos using fluorescence decay after photoconversion (FDAP).Journal of visualized experiments : JoVE · 2015Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
backgroundDegradation of the mitotic cyclins is a hallmark of the exit from mitosis. Induction of stable versions of each of the three mitotic cyclins of Drosophila, cyclins A, B, and B3, arrests mitosis with different phenotypes. We tested a recent proposal that the destruction of the different cyclins guides progress through mitosis.
resultsReal-time imaging revealed that arrest phenotypes differ because each stable cyclin affects specific mitotic events differently. Stable cyclin A prolonged or blocked chromosome disjunction, leading to metaphase arrest. Stable cyclin B allowed the transition to anaphase, but anaphase A chromosome movements were slowed, anaphase B spindle elongation did not occur, and the monooriented disjoined chromosomes began to oscillate between the spindle poles. Stable cyclin B3 prevented normal spindle maturation and blocked major mitotic exit events such as chromosome decondensation but nonetheless allowed chromosome disjunction, anaphase B, and formation of a cytokinetic furrow, which split the spindle.
conclusionsWe conclude that degradation of distinct mitotic cyclins is required to transit specific steps of mitosis: cyclin A degradation facilitates chromosome disjunction, cyclin B destruction is required for anaphase B and cytokinesis and for directional stability of univalent chromosome movements, and cyclin B3 degradation is required for proper spindle reorganization and restoration of the interphase nucleus. We suggest that the schedule of degradation of cyclin A, cyclin B, and then cyclin B3 contributes to the temporal coordination of mitotic events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.