ArticleThe Biochemical journal2001
Uterocalin, a lipocalin provisioning the preattachment equine conceptus: fatty acid and retinol binding properties, and structural characterization.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- The link between intrauterine adhesions and impaired reproductive performance: a systematic review of the literature.BMC pregnancy and childbirth · 2022Pooled it
- Relationship between the estrus duration in cyclic mares and the endometrial gene expression on day 7 post-ovulation.Veterinary research communications · 2026Article
- The immunomodulatory p43 secreted protein of Trichuris whipworm parasites is a lipid carrier that binds signalling lipids and precursors.Scientific reports · 2025Article
- The early pregnancy in mares - What do we still not know?Veterinary and animal science · 2025Review
- Early Embryonic Development in Agriculturally Important Species.Animals : an open access journal from MDPI · 2024Review
- Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy.FASEB bioAdvances · 2022Article
- Conception and early pregnancy in the mare: lipidomics the unexplored frontier.Reproduction & fertility · 2022Review
- Spatiotemporal endometrial transcriptome analysis revealed the luminal epithelium as key player during initial maternal recognition of pregnancy in the mare.Scientific reports · 2021Article
- β-Lactoglobulin and Glycodelin: Two Sides of the Same Coin?Frontiers in physiology · 2021Review
- Asynchronous Embryo Transfer Followed by Comparative Transcriptomic Analysis of Conceptus Membranes and Endometrium Identifies Processes Important to the Establishment of Equine Pregnancy.International journal of molecular sciences · 2020Article
- The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses.Animals : an open access journal from MDPI · 2020Review
- Logistic regression analyses of factors affecting fertility of intrauterine adhesions patients.Annals of translational medicine · 2020Article
- Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease.Cell reports · 2018Article
- Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse.Scientific reports · 2018Article
- Rapid changes in Atlantic grey seal milk from birth to weaning - immune factors and indicators of metabolic strain.Scientific reports · 2017Article
- Pulse of inflammatory proteins in the pregnant uterus of European polecats (Royal Society open science · 2017Article
- Hexokinase 2 drives glycogen accumulation in equine endometrium at day 12 of diestrus and pregnancy.Reproductive biology and endocrinology : RB&E · 2017Article
- Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle.BMC genomics · 2015Article
- Molecular characterization and functions of fatty acid and retinoid binding protein gene (Ab-far-1) in Aphelenchoides besseyi.PloS one · 2013Article
- Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The equine conceptus is surrounded by a fibrous capsule that persists until about day 20 of pregnancy, whereupon the capsule is lost, the conceptus attaches to the endometrium and placentation proceeds. Before attachment, the endometrium secretes in abundance a protein of the lipocalin family, uterocalin. The cessation of secretion coincides with the end of the period during which the conceptus is enclosed in its capsule, suggesting that uterocalin is essential for the support of the embryo before direct contact between maternal and foetal tissues is established. Using recombinant protein and fluorescence-based assays, we show that equine uterocalin binds the fluorescent fatty acids 11-(dansylamino)undecanoic acid, dansyl-D,L-alpha-amino-octanoic acid and cis-parinaric acid, and, by competition, oleic, palmitic, arachidonic, docosahexaenoic, gamma-linolenic, cis-eicosapentaenoic and linoleic acids. Uterocalin also binds all-trans-retinol, the binding site for which is coincident or interactive with that for fatty acids. Molecular modelling and intrinsic fluorescence analysis of the wild-type protein and a Trp-->Glu mutant protein indicated that uterocalin has an unusually solvent-exposed Trp side chain projecting from its large helix directly into solvent. This feature is unusual among lipocalins and might relate to binding to, and uptake by, the trophoblast. Uterocalin therefore has the localization and binding activities for the provisioning of the equine conceptus with lipids including those essential for morphogenesis and pattern formation. The possession of a fibrous capsule surrounding the conceptus might be an ancestral condition in mammals; homologues of uterocalin might be essential for early development in marsupials and in eutherians in which there is a prolonged preimplantation period.
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