ArticleThorax2001
Intracellular cytokine repertoire in different T cell subsets from patients with sarcoidosis.
Article in Thorax, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 74 citations in OpenAlex.
- SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8Science translational medicine · 2023Article
- Circulating Regulatory T Cell Subsets in Patients with Sarcoidosis.Diagnostics (Basel, Switzerland) · 2023Article
- Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study.Archives of rheumatology · 2023Article
- Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis.American journal of respiratory and critical care medicine · 2021Article
- The Role of Diverse Immune Cells in Sarcoidosis.Frontiers in immunology · 2021Review
- Molecular profiling in sarcoidosis.Current opinion in pulmonary medicine · 2020Review
- T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis.Frontiers in immunology · 2020Article
- CXCL9 and CXCL10 are differentially associated with systemic organ involvement and pulmonary disease severity in sarcoidosis.Respiratory medicine · 2020Article
- Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis.Respiratory medicine · 2019Article
- Potential immunotherapies for sarcoidosis.Expert opinion on biological therapy · 2018Review
- Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways.Mucosal immunology · 2016Article
- IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.American journal of respiratory and critical care medicine · 2016Article
- Imbalance between Th17 and regulatory T-Cells in sarcoidosis.International journal of molecular sciences · 2013Article
- Sarcoidosis: Immunopathogenesis and Immunological Markers.International journal of chronic diseases · 2013Review
- The clinical and immunologic features of pulmonary fibrosis in sarcoidosis.Translational research : the journal of laboratory and clinical medicine · 2012Article
- The potential of the immunological markers of sarcoidosis in exhaled breath and peripheral blood as future diagnostic and monitoring techniques.Inflammopharmacology · 2011Review
- M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis.The American journal of pathology · 2011Article
- Serratia pneumonia presenting as hemoptysis in a patient with sarcoidosis: a case report.International journal of general medicine · 2011Article
- Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia.Clinical and experimental immunology · 2009Article
- Th1/Th2 cytokine pattern in bronchoalveolar lavage fluid and induced sputum in pulmonary sarcoidosis.BMC pulmonary medicine · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary sarcoidosis is characterised by a mononuclear alveolitis with a predominance of CD4+ T cells and macrophages. We determined the intracellular expression of interferon (IFN)gamma, interleukin (IL)-2, tumour necrosis factor (TNF)alpha, IL-4, IL-5 and IL-10 in CD4+ and CD8+, naive and memory lymphocytes from blood and bronchoalveolar lavage (BAL) fluid using three colour flow cytometry.
methodsEighteen untreated patients with pulmonary sarcoidosis were evaluated and stratified according to whether they had acute or chronic disease.
resultsSignificantly more T cells expressed Th1 than Th2 type cytokines in both BAL fluid and peripheral blood samples, regardless of clinical presentation. Significantly greater proportions of T cells secreted Th1 type cytokines in BAL fluid than in peripheral blood. Th1 type cytokines were more frequently expressed by peripheral and alveolar T cells in acute disease than in chronic disease. There were no significant differences between CD4+ and CD8+ T cells. Concerning naive and memory lymphocytes, significantly higher CD45RO:CD45RA ratios were found in BAL fluid than in blood, and increased expression of Th2 type cytokines was found in peripheral compared with alveolar memory T cells.
conclusionsOur data support the immunopathogenetic concept of Th1/Th2 imbalance and compartmentalisation in pulmonary sarcoidosis and suggest that the cytokine patterns change during the course of disease. Expression of Th2 type cytokines in memory lymphocytes is decreased in the alveolar compartment compared with peripheral blood.
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