ArticleMolecular biology of the cell2001
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 112 citations in OpenAlex.
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- Alleviating the unwanted effects of oxidative stress on Aβ clearance: a review of related concepts and strategies for the development of computational modelling.Translational neurodegeneration · 2023Review
- Mechanisms and functions of endocytosis in T cells.Cell communication and signaling : CCS · 2021Review
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- Influence of cellular trafficking pathway on bluetongue virus infection in ovine cells.Viruses · 2015Article
- Clathrin-independent pathways of endocytosis.Cold Spring Harbor perspectives in biology · 2014Article
- Regulation of IL-4 receptor signaling by STUB1 in lung inflammation.American journal of respiratory and critical care medicine · 2014Article
- Multifarious determinants of cytokine receptor signaling specificity.Advances in immunology · 2014Review
- F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.Nature immunology · 2012Article
- Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway.The Journal of biological chemistry · 2012Article
- Natural killer lytic-associated molecule plays a role in controlling tumor dissemination and metastasis.Frontiers in immunology · 2012Article
- The ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi's sarcoma-associated herpesvirus in endothelial cells.PLoS pathogens · 2012Article
- Cytokine signaling modulates blood-brain barrier function.Current pharmaceutical design · 2011Review
- KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation.Endocrinology · 2011Article
- Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.Nature reviews. Molecular cell biology · 2009Review
- Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging.Aging cell · 2009Article
- Control of rapsyn stability by the CUL-3-containing E3 ligase complex.The Journal of biological chemistry · 2009Article
- Autophagy in neurodegeneration and development.Biochimica et biophysica acta · 2008Review
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down-regulation of cell surface growth factor receptors plays a key role in the tight control of cellular responses. Recent reports suggest that the ubiquitin system, in addition to participating in degradation by the proteasome of cytosolic and nuclear proteins, might also be involved in the down-regulation of various membrane receptors. We have previously characterized a signal in the cytosolic part of the interleukin 2 receptor beta chain (IL2Rbeta) responsible for its targeting to late endosomes/lysosomes. In this report, the role of the ubiquitin/proteasome system on the intracellular fate of IL2Rbeta was investigated. Inactivation of the cellular ubiquitination machinery in ts20 cells, which express a thermolabile ubiquitin-activating enzyme E1, leads to a significant decrease in the degradation rate of IL2Rbeta, with little effect on its internalization. In addition, we show that a fraction of IL2Rbeta can be monoubiquitinated. Furthermore, mutation of the lysine residues of the cytosolic region of a chimeric receptor carrying the IL2Rbeta targeting signal resulted in a decreased degradation rate. When cells expressing IL2Rbeta were treated either by proteasome or lysosome inhibitors, a significant decrease in receptor degradation was observed. Our data show that ubiquitination is required for the sorting of IL2Rbeta toward degradation. They also indicate that impairment of proteasome function might more generally affect intracellular routing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.