ArticleMolecular and cellular biology2001
Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- PAXIP1 is regulated by NRF1 and is a prognosis‑related biomarker in hepatocellular carcinoma.Biomedical reports · 2025Article
- Post-Translational Modifications of PCNA in Control of DNA Synthesis and DNA Damage Tolerance-the Implications in Carcinogenesis.International journal of biological sciences · 2021Review
- The mixed lineage leukemia 4 (MLL4) methyltransferase complex is involved in transforming growth factor beta (TGF-β)-activated gene transcription.Transcription · 2018Article
- The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.The Journal of biological chemistry · 2015Article
- Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.Molecular and cellular biology · 2013Article
- Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination.Biochimica et biophysica acta · 2012Review
- Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes.Pediatric nephrology (Berlin, Germany) · 2011Review
- A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.Developmental biology · 2011Article
- The role of PTIP in maintaining embryonic stem cell pluripotency.Stem cells (Dayton, Ohio) · 2009Article
- Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways.Development (Cambridge, England) · 2009Article
- The specification and maintenance of renal cell types by epigenetic factors.Organogenesis · 2009Article
- Control of histone methylation and genome stability by PTIP.EMBO reports · 2009Review
- An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development.Molecular and cellular biology · 2008Article
- The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.Developmental cell · 2007Article
- PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.The Journal of biological chemistry · 2007Article
- Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia.Journal of the American Society of Nephrology : JASN · 2007Article
- Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.Molecular and cellular biology · 2007Article
- RTK and TGF-beta signaling pathways genes in the sea urchin genome.Developmental biology · 2006Article
- BRCT domain-containing protein PTIP is essential for progression through mitosis.Molecular and cellular biology · 2003Article
- Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Transforming growth factor beta (TGFbeta) signaling is transduced via Smad2-Smad4-DNA-binding protein complexes which bind to responsive elements in the promoters of target genes. However, the mechanism of how the complexes activate the target genes is unclear. Here we identify Xenopus Swift, a novel nuclear BRCT (BRCA1 C-terminal) domain protein that physically interacts with Smad2 via its BRCT domains. We examine the activity of Swift in relation to gene activation in Xenopus embryos. Swift mRNA has an expression pattern similar to that of Smad2. Swift has intrinsic transactivation activity and activates target gene transcription in a TGFbeta-Smad2-dependent manner. Inhibition of Swift activity results in the suppression of TGFbeta-induced gene transcription and defective mesendoderm development. Blocking Swift function affects neither bone morphogenic protein nor fibroblast growth factor signaling during early development. We conclude that Swift is a novel coactivator of Smad2 and that Swift has a critical role in embryonic TGFbeta-induced gene transcription. Our results suggest that Swift may be a general component of TGFbeta signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.