ArticleThe Journal of biological chemistry2001
Identification of a novel structural variant of the alpha 6 integrin.
Article in The Journal of biological chemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Biophysical phenotype mixtures reveal advantages for tumor muscle invasion in vivo.Biophysical journal · 2023Article
- The burden of diabetes on the soft tissue seal surrounding the dental implants.Frontiers in physiology · 2023Review
- Identification of distinct N-glycosylation patterns on extracellular vesicles from small-cell and non-small-cell lung cancer cells.The Journal of biological chemistry · 2022Article
- Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell-Cell Biophysical Properties in Prostate Cancer.Cancer research · 2019Article
- Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions.Molecular biology of the cell · 2019Article
- Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization.Molecular & cellular proteomics : MCP · 2019Article
- α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction.Stem cell research & therapy · 2018Review
- Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.American journal of translational research · 2016Article
- Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines.Biochemical and biophysical research communications · 2014Article
- RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis.Cancers · 2012Article
- Integrin involvement in freeze resistance of androgen-insensitive prostate cancer.Prostate cancer and prostatic diseases · 2010Article
- Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis.Cancer research · 2009Article
- Human Cell Surface Receptors as Molecular Imaging Candidates for Metastatic Prostate Cancer.The open prostate cancer journal · 2009Article
- Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function.The Journal of biological chemistry · 2008Article
- Temporal and spatial regulation of integrins during development.Current opinion in cell biology · 2008Review
- Spatially and temporally regulated alpha6 integrin cleavage during Xenopus laevis development.Biochemical and biophysical research communications · 2008Article
- Integrin A6 Cleavage in Mouse Skin Tumors.The open cancer journal · 2008Article
- The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model.PloS one · 2008Article
- Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins.Cancer gene therapy · 2007Article
- Integrin alpha6 cleavage: a novel modification to modulate cell migration.Experimental cell research · 2007Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The alpha(6) integrin is a 140-kDa (nonreduced) laminin receptor. We have identified a novel 70-kDa (nonreduced) form of the alpha(6) integrin called alpha(6)p for the latin word parvus, meaning small. The variant was immunoprecipitated from human cells using four different alpha(6)-specific monoclonal antibodies but not with alpha(3) or alpha(5) antibodies. The alpha(6)p integrin contained identical amino acid sequences within exons 13--25, corresponding to the extracellular "stalk region" and the cytoplasmic tail of the alpha(6) integrin. The light chains of alpha(6) and alpha(6)p were identical as judged by alpha(6)A-specific antibodies and electrophoretic properties. The alpha(6)p variant paired with either beta(1) or beta(4) subunits and was retained on the cell surface three times longer than alpha(6). Reverse transcription/polymerase chain reaction analysis revealed a single polymerase chain reaction product. The alpha(6)p variant was found in human prostate (DU145H, LnCaP, PC3) and colon (SW480) cancer cell lines but not in normal prostate (PrEC), breast cancer (MCF-7), or lung cancer (H69) cell lines or a variant of a prostate carcinoma cell line (PC3-N). Protein levels of alpha(6)p increased 3-fold during calcium-induced terminal differentiation in a normal mouse keratinocyte model system. A novel form of the alpha(6) integrin exists on cell surfaces that contains a dramatically altered extracellular domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.