ArticleEnvironmental health perspectives2001
Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat.
Article in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- The effect of prenatal fumonisin B exposure on bone innervation in newborn Wistar rats.Journal of veterinary research · 2024Article
- The role of chromatin-modifying enzymes and histone modifications in the modulation of p16 gene in fumonisin BMycotoxin research · 2023Article
- Review
- Investigation of the Genotoxic Potential of the Marine Toxin C17-SAMT Using the In Vivo Comet and Micronucleus Assays.Marine drugs · 2022Article
- Basal Blood Morphology, Serum Biochemistry, and the Liver and Muscle Structure of Weaned Wistar Rats Prenatally Exposed to Fumonisins.Animals : an open access journal from MDPI · 2022Article
- The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.International journal of molecular sciences · 2021Article
- Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression and Immunolocalization in Bone and Cartilage in Newborn Offspring Prenatally Exposed to Fumonisins.International journal of molecular sciences · 2021Article
- Research Progress on Fumonisin B1 Contamination and Toxicity: A Review.Molecules (Basel, Switzerland) · 2021Review
- Review
- Rhamnolipid Biosurfactant againstFrontiers in microbiology · 2016Article
- Review
- Amelioration of renal carcinogenesis by bee propolis: a chemo preventive approach.Toxicology international · 2013Article
- Growth performance, haematology and serum biochemistry of African catfish (Clarias gariepinus) fingerlings fed graded levels of dietary fumonisin B1.Mycotoxin research · 2010Article
- Article
- Complex etiology and pathology of mycotoxic nephropathy in South African pigs.Mycotoxin research · 2010Article
- Expanded genetic map of Gibberella moniliformis (Fusarium verticillioides).Applied and environmental microbiology · 2002Article
- An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.Environmental health perspectives · 2001Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fumonisin B1(FB1) is a fungal metabolite of Fusarium verticillioides (= F. moniliforme), a fungus that grows on many crops worldwide. Previous studies demonstrated that male BD IX rats consuming diets containing 50 ppm fumonisin B1 developed hepatocellular carcinomas. In our recent studies, diets containing FB1 at 50 ppm or higher concentrations induced renal tubule carcinomas in male F344/N/Nctr BR rats and hepatocellular carcinomas in female B6C3F1/Nctr BR mice. The carcinogenicity of FB1 in rats and mice is not due to DNA damage, as several laboratories have demonstrated that FB1 is not a genotoxin. FB1 induces apoptosis in cells in vitro. Including FB1 in the diets of rats results in increased hepatocellular and renal tubule epithelial cell apoptosis. In studies with F344/N/Nctr BR rats consuming diets containing up to 484 ppm FB1 for 28 days, female rats demonstrated more sensitivity than male rats in the induction of hepatocellular apoptosis and mitosis. Conversely, induction of renal tubule apoptosis and regeneration were more pronounced in male than in female rats. Induction of renal tubule apoptosis and hyperplasia correlated with the incidence of renal tubule carcinomas that developed in the 2-year feeding study with FB1 in the F344/N/Nctr BR rats. The data are consistent with the hypothesis that the induction of renal tubule carcinomas in male rats could be partly due to the continuous compensatory regeneration of renal tubule epithelial cells in response to the induction of apoptosis by fumonisin B1.
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