ArticleGenes & development2001
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 205 citations in OpenAlex.
- NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions.bioRxiv : the preprint server for biology · 2025Article
- CRISPR Screening Reveals a Novel Role for FOXH1 in Regulating Pluripotency of Porcine Embryonic Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness.Nature communications · 2024Article
- Data integration and inference of gene regulation using single-cell temporal multimodal data with scTIE.Genome research · 2024Article
- scTIE: data integration and inference of gene regulation using single-cell temporal multimodal data.bioRxiv : the preprint server for biology · 2023Article
- The Fox Gene Repertoire in the Annelid Owenia fusiformis Reveals Multiple Expansions of the foxQ2 Class in Spiralia.Genome biology and evolution · 2022Article
- Dissecting signaling hierarchies in the patterning of the mouse primitive streak using micropatterned EpiLC colonies.Stem cell reports · 2022Article
- ERK1/2 is an ancestral organising signal in spiral cleavage.Nature communications · 2022Article
- Gain of gene regulatory network interconnectivity at the origin of vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genetics of Transposition of Great Arteries: Between Laterality Abnormality and Outflow Tract Defect.Journal of cardiovascular translational research · 2021Review
- Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage.Biology open · 2021Article
- PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly.Science advances · 2020Article
- FOXH1 Is Regulated by NANOG and LIN28 for Early-stage Reprogramming.Scientific reports · 2019Article
- Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling.Genes & development · 2019Article
- MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.Nature communications · 2019Article
- The RNA exosome nuclease complex regulates human embryonic stem cell differentiation.The Journal of cell biology · 2019Article
- FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation.BMC biology · 2019Article
- Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.Cell reports · 2019Article
- Activin/Smad2 and Wnt/β-catenin up-regulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human embryonic stem cells.The Journal of biological chemistry · 2018Article
- Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The node and the anterior visceral endoderm (AVE) are important organizing centers that pattern the mouse embryo by establishing the anterior-posterior (A-P), dorsal-ventral (D-V), and left-right (L-R) axes. Activin/nodal signaling through the Smad2 pathway has been implicated in AVE formation and in morphogenesis of the primitive streak, the anterior end of which gives rise to the node. The forkhead DNA-binding protein, FoxH1 (or Fast), functions as a Smad DNA-binding partner to regulate transcription in response to activin signaling. Here, we show that deletion of FoxH1 in mice results in failure to pattern the anterior primitive streak (APS) and form node, prechordal mesoderm, notochord, and definitive endoderm. In contrast, formation of the AVE can occur in the absence of FoxH1. The FoxH1 mutant phenotype is remarkably similar to that of mice deficient in the forkhead protein Foxa2 (HNF3beta), and we show that Foxa2 expression is dependent on FoxH1 function. These results show that FoxH1 functions in an activin/nodal-Smad signaling pathway that acts upstream of Foxa2 and is required specifically for patterning the APS and node in the mouse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.