ArticleGenes & development2001
Using viral species specificity to define a critical protein/RNA interaction surface.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- HIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors.PLoS pathogens · 2016Article
- Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.Retrovirology · 2014Article
- Nuclear RNA export and packaging functions of HIV-1 Rev revisited.Journal of virology · 2010Article
- Coupling of dephosphorylation and nuclear export of Smads in TGF-beta signaling.Methods in molecular biology (Clifton, N.J.) · 2010Article
- Article
- Amino acid residue doublet propensity in the protein-RNA interface and its application to RNA interface prediction.Nucleic acids research · 2006Article
- Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.Current biology : CB · 2005Article
- Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs.RNA (New York, N.Y.) · 2005Article
- Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes.Nucleic acids research · 2005Article
- Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis.Journal of virology · 2004Article
- Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference.Journal of virology · 2002Article
- Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs.Journal of virology · 2002Article
- The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Both ran and importins have the ability to function as nuclear mRNA export factors.RNA (New York, N.Y.) · 2002Article
- Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.Molecular and cellular biology · 2002Article
- Retroviral RNA elements integrate components of post-transcriptional gene expression.Life sciences · 2001Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The Tap protein mediates the sequence-specific nuclear export of mRNAs bearing the retroviral constitutive transport element (CTE) and also plays a critical role in the sequence nonspecific export of cellular mRNAs. Previously, we have demonstrated that CTE function displays species specificity, that is, the CTE functions in human but not quail cells. Here, we demonstrate that quail Tap fails to support CTE function because it cannot bind the CTE. However, changing a single residue in quail Tap, glutamine 246, to arginine, the residue found in human Tap, rescues both CTE function and CTE binding. This residue, which is located on the exterior of a recently reported molecular structure of Tap, defines a surface on Tap that is critical for CTE binding. These data emphasize the potential importance of cross-species genetic complementation in the identification and characterization of cellular factors that are critical for different aspects of viral replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.