ArticleJournal of virology2001
Comparison of replication-competent molecular clones of porcine endogenous retrovirus class A and class B derived from pig and human cells.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Analysis of PERV-C superinfection resistance using HA-tagged viruses.Retrovirology · 2023Article
- High Prevalence of Recombinant Porcine Endogenous Retroviruses (PERV-A/Cs) in Minipigs: A Review on Origin and Presence.Viruses · 2021Review
- Multiplatform next-generation sequencing identifies novel RNA molecules and transcript isoforms of the endogenous retrovirus isolated from cultured cells.FEMS microbiology letters · 2018Article
- Porcine Endogenous Retrovirus (PERV) - Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells.Frontiers in microbiology · 2018Review
- Article
- Review
- Role of DNA methylation in expression and transmission of porcine endogenous retroviruses.Journal of virology · 2013Article
- Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.Clinical microbiology reviews · 2012Review
- Molecular characterization of a novel gammaretrovirus in killer whales (Orcinus orca).Journal of virology · 2009Article
- Characterization of the replication-competent porcine endogenous retrovirus class B molecular clone originated from Korean domestic pig.Virus genes · 2009Article
- Identification of residues outside of the receptor binding domain that influence the infectivity and tropism of porcine endogenous retrovirus.Journal of virology · 2008Article
- Mice transgenic for a human porcine endogenous retrovirus receptor are susceptible to productive viral infection.Journal of virology · 2006Article
- Reliable classification and recombination analysis of porcine endogenous retroviruses.Virus genes · 2005Article
- Evolutionary spread and recombination of porcine endogenous retroviruses in the suiformes.Journal of virology · 2005Article
- Evidence and consequence of porcine endogenous retrovirus recombination.Journal of virology · 2004Article
- Determinants of high titer in recombinant porcine endogenous retroviruses.Journal of virology · 2004Article
- Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature Swine.Journal of virology · 2004Article
- Absence of replication-competent human-tropic porcine endogenous retroviruses in the germ line DNA of inbred miniature Swine.Journal of virology · 2004Article
- Relative age of proviral porcine endogenous retrovirus sequences in Sus scrofa based on the molecular clock hypothesis.Journal of virology · 2003Article
- Characterization of two porcine endogenous retrovirus integration loci and variability in pigs.Immunogenetics · 2003Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertically transmitted endogenous retroviruses pose an infectious risk in the course of pig-to-human transplantation of cells, tissues, and organs. Two classes of polytropic type C porcine endogenous retroviruses (PERV) which are infectious for human cells in vitro are known. Recently, we described the cloning and characterization of replication-competent PERV-B sequences from productively infected human cells (F. Czauderna, N. Fischer, K. Boller, R. Kurth, and R. R. Tönjes, J. Virol. 74:4028-4038, 2000). Here, we report the isolation of infectious molecular PERV-A and PERV-B clones from pig cells and compare these proviruses with clones derived from infected human 293 cells. In addition to clone PERV-A(42) derived from 293 cells, four "native" full-length proviral PERV sequences derived from a genomic library of the porcine cell line PK15 were isolated. Three identical class A clones, designated PK15-PERV-A(42), PK15-PERV-A(45), and PK15-PERV-A(58), and one class B clone, PK15-PERV-B(213), were characterized. PK15-PERV-B(213) is highly homologous but distinct from the previously described clone PERV-B(43). PK15-PERV-A(58) demonstrates close homology to PERV-A(42) in env and to PERV-C in long terminal repeat, gag, and pro/pol sequences. All three PERV clones described here were replication competent upon infection of susceptible cell lines. The findings suggest that the pig genome harbors a limited number of infectious PERV-A and -B sequences.
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