ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Gene Therapy in Crohn's Disease: Current Preclinical Challenges and Future Translational Avenues.Biomedicines · 2025Review
- Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.PLoS genetics · 2020Article
- AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy.Frontiers in molecular neuroscience · 2020Review
- A principled strategy for mapping enhancers to genes.Scientific reports · 2019Article
- Developing myelin specific promoters for schwannoma gene therapy.Journal of neuroscience methods · 2019Article
- Neuroprotective effect of ischemic postconditioning on sciatic nerve transection.Neural regeneration research · 2018Article
- Gene therapy targeting oligodendrocytes provides therapeutic benefit in a leukodystrophy model.Brain : a journal of neurology · 2017Article
- Autophagy Promotes Peripheral Nerve Regeneration and Motor Recovery Following Sciatic Nerve Crush Injury in Rats.Journal of molecular neuroscience : MN · 2016Article
- Finding degrees of separation: experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting.Journal of neuroscience methods · 2014Review
- Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.PloS one · 2014Article
- Schwann cell myelination requires Dynein function.Neural development · 2012Article
- Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Towards resolving the transcription factor network controlling myelin gene expression.Nucleic acids research · 2011Article
- Regulatory modules function in a non-autonomous manner to control transcription of the mbp gene.Nucleic acids research · 2011Article
- Regulation of the PMP22 gene through an intronic enhancer.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer.Nucleic acids research · 2011Article
- Transgenic mouse models of multiple sclerosis.Cellular and molecular life sciences : CMLS · 2010Review
- Characterization of the regulatory region of the dopa decarboxylase gene in Medaka: an in vivo green fluorescent protein reporter assay combined with a simple TA-cloning method.Molecular biotechnology · 2009Article
- Review
- P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In peripheral nerves, large caliber axons are ensheathed by myelin-elaborating Schwann cells. Multiple lines of evidence demonstrate that expression of the genes encoding myelin structural proteins occurs in Schwann cells in response to axonal instructions. To gain further insight into the mechanisms controlling myelin gene expression, we used reporter constructs in transgenic mice to search for the DNA elements that regulate the myelin basic protein (MBP) gene. Through this in vivo investigation, we provide evidence for the participation of multiple, widely distributed, positive and negative elements in the overall control of MBP expression. Notably, all constructs bearing a 0.6 kb far-upstream sequence, designated Schwann cell enhancer 1 (SCE1), expressed at high levels in myelin-forming Schwann cells. In addition, robust targeting activity conferred by SCE1 was shown to be independent of other MBP 5' flanking sequence. These observations suggest that SCE1 will make available a powerful tool to drive transgene expression in myelinating Schwann cells and that a focused analysis of the SCE1 sequence will lead to the identification of transcription factor binding sites that positively regulate MBP expression.
Indexed as
Identifiers
11356866PMC6762685W2165608274What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.