ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons: participants in burst generation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Who cites it
58 citing papers in PubMed, 154 citations in OpenAlex.
- The mesencephalic trigeminal neuron: electrophysiological insights into function and dysfunction.Frontiers in cellular neuroscience · 2026Review
- Contribution of proprioceptors in the mesencephalic trigeminal nucleus and their surrounding astrocytes to acidic saline-induced chronic jaw muscle pain in rodents.Frontiers in cellular neuroscience · 2026Article
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- Astrocyte-induced firing in primary afferent axons.iScience · 2025Article
- Hyperexcitability of muscle spindle afferents in jaw-closing muscles in experimental myalgia: Evidence for large primary afferents involvement in chronic pain.Experimental physiology · 2024Review
- D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion.The Journal of general physiology · 2023Article
- Different species, different gap junctions?The Journal of general physiology · 2023Article
- Modulation of SK Channels via Calcium Buffering Tunes Intrinsic Excitability of Parvalbumin Interneurons in Neuropathic Pain: A Computational and Experimental Investigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Distinct mechanisms underlie electrical coupling resonance and its interaction with membrane potential resonance.Frontiers in systems biology · 2023Article
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Activation of Voltage-Gated NaBiomedicines · 2022Article
- Comparative study between radiofrequency-induced and muscimol-induced inhibition of cultured networks of cortical neuron.PloS one · 2022Article
- Membrane Resonance in Pyramidal and GABAergic Neurons of the Mouse Perirhinal Cortex.Frontiers in cellular neuroscience · 2021Article
- Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Frequency-dependent responses of neuronal models to oscillatory inputs in current versus voltage clamp.Biological cybernetics · 2019Article
- Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons.PLoS computational biology · 2019Article
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Membrane potential resonance in non-oscillatory neurons interacts with synaptic connectivity to produce network oscillations.Journal of computational neuroscience · 2019Article
- Spiking resonances in models with the same slow resonant and fast amplifying currents but different subthreshold dynamic properties.Journal of computational neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Trigeminal mesencephalic (Mes V) neurons are critical components of the circuits controlling oral-motor activity. The possibility that they can function as interneurons necessitates a detailed understanding of the factors controlling their soma excitability. Using whole-cell patch-clamp recording, in vitro, we investigated the development of the ionic mechanisms responsible for the previously described subthreshold membrane oscillations and rhythmical burst discharge in Mes V neurons from rats ages postnatal day (P) 2-12. We found that the oscillation amplitude and frequency increased during development, whereas bursting emerged after P6. Furthermore, when bursting was initiated, the spike frequency was largely determined by the oscillation frequency. Frequency domain analysis indicated that these oscillations emerged from the voltage-dependent resonant properties of Mes V neurons. Low doses of 4-aminopyridine (<100 microm) reduced the oscillations and abolished resonance in most neurons, suggesting that the resonant current is a steady-state K(+) current (I(4-AP)). Sodium ion replacement or TTX reduced substantially the oscillations and peak amplitude of the resonance, suggesting the presence of a persistent Na(+) current (I(NaP)) that functions to amplify the resonance and facilitate the emergence of subthreshold oscillations and bursting.
Indexed as
Identifiers
11356860PMC6762704W1548653509What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.