ArticleNeurogenetics2001
Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress.
Article in Neurogenetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Review
- Article
- Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease.Frontiers in neuroscience · 2018Article
- Transcriptome Analysis of Bronchoalveolar Lavage Fluid From Children WithFrontiers in immunology · 2018Article
- Duplication and Sub/Neofunctionalization ofG3 (Bethesda, Md.) · 2017Article
- Drosophila divalent metal ion transporter Malvolio is required in dopaminergic neurons for feeding decisions.Genes, brain, and behavior · 2017Article
- Thymus atrophy and double-positive escape are common features in infectious diseases.Journal of parasitology research · 2012Article
- Toxoplasma on the brain: understanding host-pathogen interactions in chronic CNS infection.Journal of parasitology research · 2012Article
- Natural history of SLC11 genes in vertebrates: tales from the fish world.BMC evolutionary biology · 2011Article
- The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer?FEMS immunology and medical microbiology · 2007Review
- Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1).The Biochemical journal · 2004Article
- SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1.Pflugers Archiv : European journal of physiology · 2004Review
- SLC11A1 (formerly NRAMP1) and disease resistance.Cellular microbiology · 2001Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The gene Nramp1 encoding the natural resistance-associated macrophage protein (Nramp1) influences susceptibility to intracellular infections and autoimmune diseases, and the humoral response to stress. Nramp1 functions as a proton/divalent cation antiporter in the membranes of late endosomes/lysosomes, regulating cytoplasmic iron levels in macrophages. The Drosophila homologue of Nramp1 is expressed in sensory neurons and macrophages, and influences taste behaviour directly through divalent cation transport. Here we demonstrate that murine Nramp1 is also expressed on neurons as well as microglial cells in the brain and influences the behavioural response to stress, hypothalamus-pituitary-adrenal (HPA) axis activation and mortality following Toxoplasma gondii infection in control and prestressed mice. We hypothesise that, although differences in HPA activation translate into differences in adrenal enlargement and basal circulating corticosterone levels, the primary influence of Nramp1 is at the level of the neuronal response to stress. These results provide new insight into the possible roles of divalent cation transporters of the Nramp gene family in regulating metal ion homeostasis in the brain and its pathological implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.