ArticleProceedings of the National Academy of Sciences of the United States of America2001
CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 124 citations in OpenAlex.
- Neuroinflammation: Extinguishing a blaze of T cells.Immunological reviews · 2022Review
- Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation.Brain sciences · 2020Article
- c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.Journal of neuroinflammation · 2020Article
- IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation.Frontiers in immunology · 2020Article
- Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE.Cellular & molecular immunology · 2019Review
- Experimental Autoimmune Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis (MS).Cold Spring Harbor perspectives in medicine · 2018Review
- Naringenin Modifies the Development of Lineage-Specific Effector CD4Frontiers in immunology · 2018Article
- Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis.Scientific reports · 2016Article
- Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?Central-European journal of immunology · 2016Review
- Role of TRIF Small Interference RNA (siRNA) in Chronic Experimental Allergic Encephalomyelitis (EAE).Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- CD8(+) T-Cells as Immune Regulators of Multiple Sclerosis.Frontiers in immunology · 2015Review
- Immune regulation of multiple sclerosis by CD8+ T cells.Immunologic research · 2014Review
- Intravenous immunoglobulin modulates the expansion and cytotoxicity of CD8+ T cells.Immunology · 2014Article
- The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Working out mechanisms of controlled/physiologic inflammation in the GI tract.Immunologic research · 2012Review
- Global expression profiling of peripheral Qa-1-restricted CD8αα+TCRαβ+ regulatory T cells reveals innate-like features: implications for immune-regulatory repertoire.Human immunology · 2012Article
- Epstein-Barr virus peptide presented by HLA-E is predominantly recognized by CD8(bright) cells in multiple sclerosis patients.PloS one · 2012Article
- The immunomodulatory and neuroprotective effects of mesenchymal stem cells (MSCs) in experimental autoimmune encephalomyelitis (EAE): a model of multiple sclerosis (MS).International journal of molecular sciences · 2012Review
- Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells.Seminars in immunology · 2011Review
- Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin.Brain : a journal of neurology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Trimolecular interactions between the T cell antigen receptor and MHC/peptide complexes, together with costimulatory molecules and cytokines, control the initial activation of naive T cells and determine whether the helper precursor cell differentiates into either T helper (TH)1 or TH2 effector cells. We now present evidence that regulatory CD8(+) T cells provide another level of control of TH phenotype during further evolution of immune responses. These regulatory CD8(+) T cells are induced by antigen-triggered CD4(+) TH1 cells during T cell vaccination and, in vitro, distinguish mature TH1 from TH2 cells in a T cell antigen receptor Vbeta-specific and Qa-1-restricted manner. In vivo, protection from experimental autoimmune encephalomyelitis (EAE) induced by T cell vaccination depends on CD8(+) T cells, and myelin basic protein-reactive TH1 Vbeta8(+) clones, but not TH2 Vbeta8(+) clones, used as vaccine T cells, protect animals from subsequent induction of EAE. Moreover, in vivo depletion of CD8(+) T cells during the first episode of EAE results in skewing of the TH phenotype toward TH1 upon secondary myelin basic protein stimulation. These data provide evidence that CD8(+) T cells control autoimmune responses, in part, by regulating the TH phenotype of self-reactive CD4(+) T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.