ArticleProceedings of the National Academy of Sciences of the United States of America2001
BimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Sordaria, a model system to uncover links between meiotic pairing and recombination.Seminars in cell & developmental biology · 2016Review
- Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.Chromosoma · 2016Article
- Involvement of the Cohesin Cofactor PDS5 (SPO76) During Meiosis and DNA Repair in Arabidopsis thaliana.Frontiers in plant science · 2015Article
- Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis.The Journal of cell biology · 2009Article
- Coupling meiotic chromosome axis integrity to recombination.Genes & development · 2008Article
- APRIN is a unique Pds5 paralog with features of a chromatin regulator in hormonal differentiation.The Journal of steroid biochemistry and molecular biology · 2008Article
- Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast.The Journal of cell biology · 2006Article
- SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae.Genes & development · 2006Article
- Review
- A mechanical basis for chromosome function.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Meiotic double-strand breaks at the interface of chromosome movement, chromosome remodeling, and reductional division.Genes & development · 2003Article
- Fission yeast Sap1 protein is essential for chromosome stability.Eukaryotic cell · 2003Article
- Intra-G1 arrest in response to UV irradiation in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BIMD of Aspergillus nidulans belongs to a highly conserved protein family implicated, in filamentous fungi, in sister-chromatid cohesion and DNA repair. We show here that BIMD is chromosome associated at all stages, except from late prophase through anaphase, during mitosis and meiosis, and is involved in several aspects of both programs. First, bimD(+) function must be executed during S through M. Second, in bimD6 germlings, mitotic nuclear divisions and overall cellular program occur more rapidly than in wild type. Thus, BIMD, an abundant chromosomal protein, is a negative regulator of normal cell cycle progression. Third, bimD6 reduces the level of mitotic interhomolog recombination but does not alter the ratio between crossover and noncrossover outcomes. Moreover, bimD6 is normal for intrachromosomal recombination. Therefore, BIMD is probably not involved in the enzymology of recombinational repair per se. Finally, during meiosis, staining of the Sordaria ortholog Spo76p delineates robust chromosomal axes, whereas BIMD stains all chromatin. SPO76 and bimD are functional homologs with respect to their roles in mitotic chromosome metabolism but not in meiosis. We propose that BIMD exerts its diverse influences on cell cycle progression as well as chromosome morphogenesis and recombination by modulating chromosome structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.