ArticleAmerican journal of human genetics2001
Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy.Genome research · 2024Article
- The Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model.Behavior genetics · 2024Article
- Heritability Estimation Approaches Utilizing Genome-Wide Data.Current protocols · 2023Review
- A fast linkage method for population GWAS cohorts with related individuals.Genetic epidemiology · 2023Article
- Scalable Nonparametric Prescreening Method for Searching Higher-Order Genetic Interactions Underlying Quantitative Traits.Genetics · 2019Article
- A scalable estimator of SNP heritability for biobank-scale data.Bioinformatics (Oxford, England) · 2018Article
- A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES.The annals of applied statistics · 2017Article
- Phenome-wide heritability analysis of the UK Biobank.PLoS genetics · 2017Article
- A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.PLoS genetics · 2017Article
- An efficient method to handle the 'large p, small n' problem for genomewide association studies using Haseman-Elston regression.Journal of genetics · 2016Article
- A re-formulation of generalized linear mixed models to fit family data in genetic association studies.Frontiers in genetics · 2015Article
- Leveraging population admixture to characterize the heritability of complex traits.Nature genetics · 2014Article
- Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples.PLoS genetics · 2014Article
- Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression.Frontiers in genetics · 2014Article
- Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs.American journal of human genetics · 2013Article
- Estimation and partition of heritability in human populations using whole-genome analysis methods.Annual review of genetics · 2013Review
- Epistatic association mapping in homozygous crop cultivars.PloS one · 2011Article
- A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes.Statistics in biosciences · 2009Article
- Influence of genotyping error in linkage mapping for complex traits--an analytic study.BMC genetics · 2008Article
- Robust score statistics for QTL linkage analysis.American journal of human genetics · 2008Article
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Abstract
The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the "revisited" method, which uses the cross-product--rather than the squared difference--in sib trait values, is, in general, less powerful than VC models. In this report, we clarify the relative efficiencies of existing Haseman-Elston methods and show how a new Haseman-Elston method can be constructed to have power equivalent to that of VC models. This method uses as the dependent variable a linear combination of squared sums and squared differences, in which the weights are determined by the overall trait correlation between sibs in a population. We show how this method can be used for both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of such selected samples.
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