ArticleNucleic acids research2001
Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Survivin-Targeting Antisense Oligonucleotides in Cancer Therapy.Molecules (Basel, Switzerland) · 2026Review
- Mechanisms of Action of the US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024Review
- RNA interference as a novel treatment strategy for chronic hepatitis B infection.Clinical and molecular hepatology · 2022Review
- Microarrays for identifying binding sites and probing structure of RNAs.Nucleic acids research · 2015Review
- Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays.The Journal of biological chemistry · 2012Article
- siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells.Molecular and cellular biochemistry · 2012Article
- Ezrin mRNA target site selection for DNAzymes using secondary structure and hybridization thermodynamics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Variables and strategies in development of therapeutic post-transcriptional gene silencing agents.Journal of ophthalmology · 2011Article
- Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites.Retrovirology · 2007Article
- Systematic analysis of the role of target site accessibility in the activity of DNA enzymes.Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research · 2006Article
- Facilitating RNA structure prediction with microarrays.Biochemistry · 2006Article
- Rational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation.Nucleic acids research · 2006Article
- Antisense phosphorodiamidate morpholino oligomer length and target position effects on gene-specific inhibition in Escherichia coli.Antimicrobial agents and chemotherapy · 2005Article
- Probing alternative foldings of the HIV-1 leader RNA by antisense oligonucleotide scanning arrays.Nucleic acids research · 2004Article
- Molecular detection and identification of influenza viruses by oligonucleotide microarray hybridization.Journal of clinical microbiology · 2003Article
- mRNA fusion constructs serve in a general cell-based assay to profile oligonucleotide activity.Nucleic acids research · 2003Article
- Thermodynamic calculations and statistical correlations for oligo-probes design.Nucleic acids research · 2003Article
- A simple and cost-effective method for producing small interfering RNAs with high efficacy.Nucleic acids research · 2003Article
- Prioritized selection of oligodeoxyribonucleotide probes for efficient hybridization to RNA transcripts.Nucleic acids research · 2003Article
- Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu.RNA (New York, N.Y.) · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcripts representing mRNAs of three Xenopus cyclins, B1, B4 and B5, were hybridised to arrays of oligonucleotides scanning the first 120 nt of the coding region to assess the ability of the immobilised oligonucleotides to form heteroduplexes with their targets. Oligonucleotides that produced high heteroduplex yield and others that showed little annealing were assayed for their effect on translation of endogenous cyclin mRNAs in Xenopus egg extracts and their ability to promote cleavage of cyclin mRNAs in oocytes by RNase H. Excellent correlation was found between antisense potency and affinity of oligonucleotides for the cyclin transcripts as measured by the array, despite the complexity of the cellular environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.