ArticleThe Journal of cell biology2001
Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Extracellular epimorphin impairs expression and processing of profilaggrin in HaCaT keratinocytes.Cytotechnology · 2023Article
- C/EBPβ isoform-specific regulation of migration and invasion in triple-negative breast cancer cells.NPJ breast cancer · 2022Article
- Membrane translocation of t-SNARE protein syntaxin-4 abrogates ground-state pluripotency in mouse embryonic stem cells.Scientific reports · 2017Article
- Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion.Cancer informatics · 2015Article
- Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiation.Molecular and cellular biology · 2014Article
- Epimorphin is a novel regulator of the progesterone receptor isoform-a.Cancer research · 2013Article
- Article
- Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases.Cold Spring Harbor perspectives in biology · 2012Review
- Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture.Experimental cell research · 2011Article
- Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer.Journal of mammary gland biology and neoplasia · 2010Review
- Epimorphin regulates bile duct formation via effects on mitosis orientation in rat liver epithelial stem-like cells.PloS one · 2010Article
- Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.The Journal of biological chemistry · 2009Article
- Single proteins might have dual but related functions in intracellular and extracellular microenvironments.Nature reviews. Molecular cell biology · 2009Review
- The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium.Developmental biology · 2007Article
- Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis.Journal of mammary gland biology and neoplasia · 2006Review
- Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis.The Journal of clinical investigation · 2006Article
- Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.Annual review of cell and developmental biology · 2006Review
- Mfge8 is critical for mammary gland remodeling during involution.Molecular biology of the cell · 2005Article
- Myoepithelial cells in the control of mammary development and tumorigenesis: data from genetically modified mice.Journal of mammary gland biology and neoplasia · 2005Review
- Epimorphin expression in interstitial pneumonia.Respiratory research · 2005Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
We have shown previously that epimorphin (EPM), a protein expressed on the surface of myoepithelial and fibroblast cells of the mammary gland, acts as a multifunctional morphogen of mammary epithelial cells. Here, we present the molecular mechanism by which EPM mediates luminal morphogenesis. Treatment of cells with EPM to induce lumen formation greatly increases the overall expression of transcription factor CCAAT/enhancer binding protein (C/EBP)beta and alters the relative expression of its two principal isoforms, LIP and LAP. These alterations were shown to be essential for the morphogenetic activities, since constitutive expression of LIP was sufficient to produce lumen formation, whereas constitutive expression of LAP blocked EPM-mediated luminal morphogenesis. Furthermore, in a transgenic mouse model in which EPM expression was expressed in an apolar fashion on the surface of mammary epithelial cells, we found increased expression of C/EBPbeta, increased relative expression of LIP to LAP, and enlarged ductal lumina. Together, our studies demonstrate a role for EPM in luminal morphogenesis through control of C/EBPbeta expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.