Trial reportClinical pharmacokinetics2001
Effect of probenecid on the kinetics of a single oral 400mg dose of moxifloxacin in healthy male volunteers.
Trial report in Clinical pharmacokinetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers.Drug design, development and therapy · 2016Trial
- Midostaurin does not prolong cardiac repolarization defined in a thorough electrocardiogram trial in healthy volunteers.Cancer chemotherapy and pharmacology · 2012Trial
- Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid.British journal of clinical pharmacology · 2010Trial
- Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.Antimicrobial agents and chemotherapy · 2009Trial
- Gender analysis of moxifloxacin clinical trials.Journal of women's health (2002) · 2014Review
- Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials.Antimicrobial agents and chemotherapy · 2013Article
- Review
- Pharmacokinetics of moxifloxacin, a novel 8-methoxy-quinolone, in patients with renal dysfunction.British journal of clinical pharmacology · 2002Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of oral probenecid on the pharmacokinetics of oral moxifloxacin in healthy adult male volunteers. DESIGN AND
settingThis was a nonblinded, randomised, 2-way crossover study. PATIENTS AND
participants12 male Caucasian volunteers (mean age 33.7 years) participated in the study.
methodsA single oral dose of moxifloxacin 400mg was administered after an overnight fast with or without a 2-day course of probenecid 500mg twice daily starting at 1 hour before the moxifloxacin dose. There was a washout phase of at least 1 week between the 2 treatments. Samples of plasma and urine were taken according to predefined sampling schedules and the concentrations of moxifloxacin were determined with a validated high performance liquid chromatography assay with fluorescence detection. Noncompartmental pharmacokinetic data were calculated.
resultsPharmacokinetic results with and without probenecid were virtually identical except for a slight delay in absorption with probenecid, indicated by a very slightly increased time to maximum concentration and a decreased maximum concentration (approximately 10%), which was not clinically relevant. Probenecid had no significant influence on the renal elimination of moxifloxacin, suggesting urinary excretion by glomerular filtration and partial tubular reabsorption. Safety and tolerability were good, with no clinically relevant drug-related adverse events or changes in laboratory parameters.
conclusionDosage adjustments for moxifloxacin are not necessary when it is administered together with probenecid.
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.