ArticleThe Histochemical journal2001
Temporal and spatial gene expression of major bone extracellular matrix molecules during embryonic mandibular osteogenesis in rats.
Article in The Histochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 83 citations in OpenAlex.
- Matrix components in the developing bones and cartilage of embryonic chick skulls: an in situ hybridization study.Anatomical science international · 2026Article
- High-frequency low-intensity semiconductor laser irradiation enhances osteogenic differentiation of human cementoblast lineage cells.Lasers in medical science · 2024Article
- The osteocyte and its osteoclastogenic potential.Frontiers in endocrinology · 2023Review
- Functionalization with a Polyphenol-Rich Pomace Extract Empowers a Ceramic Bone Filler with In Vitro Antioxidant, Anti-Inflammatory, and Pro-Osteogenic Properties.Journal of functional biomaterials · 2021Article
- Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation.Stem cell research & therapy · 2021Article
- Chitosan-based double-faced barrier membrane coated with functional nanostructures and loaded with BMP-6.Journal of materials science. Materials in medicine · 2019Article
- Properties of carbon nanotube-dispersed Sr-hydroxyapatite injectable material for bone defects.Regenerative biomaterials · 2016Article
- Osteocalcin and osteonectin expression after double application of platelet-rich plasma in rabbits.Journal of Istanbul University Faculty of Dentistry · 2016Article
- Bone matrix calcification during embryonic and postembryonic rat calvarial development assessed by SEM-EDX spectroscopy, XRD, and FTIR spectroscopy.Journal of bone and mineral metabolism · 2016Article
- Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation.Stem cells international · 2016Review
- Effect of osteogenic differentiation medium on proliferation and differentiation of human mesenchymal stem cells in three-dimensional culture with radial flow bioreactor.Regenerative therapy · 2015Article
- A facile in vitro model to study rapid mineralization in bone tissues.Biomedical engineering online · 2014Article
- Controlled release strategies for bone, cartilage, and osteochondral engineering--Part I: recapitulation of native tissue healing and variables for the design of delivery systems.Tissue engineering. Part B, Reviews · 2013Review
- Bioreactor strategy in bone tissue engineering: pre-culture and osteogenic differentiation under two flow configurations.Tissue engineering. Part A · 2012Article
- Expression of genes for gelatinases and tissue inhibitors of metalloproteinases in periodontal tissues during orthodontic tooth movement.Journal of molecular histology · 2006Article
- Comparison of age-dependent expression of aggrecan and ADAMTSs in mandibular condylar cartilage, tibial growth plate, and articular cartilage in rats.Histochemistry and cell biology · 2006Article
- Expression of versican and ADAMTS1, 4, and 5 during bone development in the rat mandible and hind limb.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2005Article
- Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2005Article
- Distinctive expression of extracellular matrix molecules at mRNA and protein levels during formation of cellular and acellular cementum in the rat.The Histochemical journal · 2001Article
- Gene expression and immunohistochemical localization of osteonectin in association with early bone formation in the developing mandible.The Histochemical journalArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is not known how gene expression of bone extracellular matrix molecules is controlled temporally and spatially, or how it is related with morphological differentiation of osteoblasts during embryonic osteogenesis in vivo. The present study was designed to examine gene expressions of type I collagen, osteonectin, bone sialoprotein, osteopontin, and osteocalcin during mandibular osteogenesis using in situ hybridization. Wistar rat embryos 13-20 days post coitum were used. The condensation of mesenchymal cells was formed in 14-day rat embryonic mandibles and expressed genes of pro-alpha 1 (I) collagen, osteonectin, bone sialoprotein and osteopontin. Cuboidal osteoblasts surrounding the uncalcified bone matrix were seen as early as in 15-day embryonic mandibles, while flat osteoblasts lining the surface of the calcified bone were seen from 16-day embryonic mandibles. Cuboidal osteoblasts expressed pro-alpha 1(I) collagen, osteonectin and bone sialoprotein intensely but osteopontin very weakly. In contrast, flat osteoblasts expressed osteopontin very strongly. Osteocytes expressed the extracellular matrix molecules actively, in particular, osteopontin. The present study demonstrated the distinct gene expression pattern of type I collagen, osteonectin, bone sialoprotein, osteopontin and osteocalcin during embryonic mandibular osteogenesis in vivo.
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