ReviewThe Journal of physiology2001
Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord.
Review in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Developmental changes in spinal neuronal properties, motor network configuration, and neuromodulation at free-swimming stages of Xenopus tadpoles.Journal of neurophysiology · 2018Article
- Article
- Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation.Toxins · 2016Article
- Decoding the organization of spinal circuits that control locomotion.Nature reviews. Neuroscience · 2016Review
- A synaptic mechanism for network synchrony.Frontiers in cellular neuroscience · 2014Review
- Calcium dynamics during NMDA-induced membrane potential oscillations in lamprey spinal neurons--contribution of L-type calcium channels (CaV1.3).The Journal of physiology · 2013Article
- The contribution of synaptic inputs to sustained depolarizations in reticulospinal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons.The Journal of physiology · 2007Article
- Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2007Review
- Modeling the mammalian locomotor CPG: insights from mistakes and perturbations.Progress in brain research · 2007Review
- Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion.The Journal of physiology · 2006Article
- Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Mechanisms of rhythm generation in a spinal locomotor network deprived of crossed connections: the lamprey hemicord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Dendritic control of spontaneous bursting in cerebellar Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Estimating the strength and direction of functional coupling in the lamprey spinal cord.Journal of computational neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intrinsic function of the spinal network that generates locomotion can be studied in the isolated brainstem-spinal cord of the lamprey, a lower vertebrate. The motor pattern underlying locomotion can be elicited in the isolated spinal cord. The network consists of excitatory glutamatergic and inhibitory glycinergic interneurones with known connectivity. The current review addresses the different subtypes of ion channels that are present in the cell types that constitute the network. In particular the roles of the different subtypes of Ca2+ channels and potassium channels that regulate integrated neuronal functions, like frequency regulation, spike frequency adaptation and properties that are important for generating features of the motor pattern (e.g. burst termination), are reviewed. By knowing the role of an ion channel at the cellular level, we also, based on previous knowledge of network connectivity, can understand which effect a given ion channel may exert at the different levels from molecule and cell to network and behaviour.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.